Chapter title |
Mechanism of Traumatic Brain Injury at Distant Locations After Exposure to Blast Waves: Preliminary Results from Animal and Phantom Experiments.
|
---|---|
Chapter number | 1 |
Book title |
Intracranial Pressure and Brain Monitoring XV
|
Published in |
Acta neurochirurgica Supplement, January 2016
|
DOI | 10.1007/978-3-319-22533-3_1 |
Pubmed ID | |
Book ISBNs |
978-3-31-922532-6, 978-3-31-922533-3
|
Authors |
Atsuhiro Nakagawa MD, PhD, Kiyonobu Ohtani D.Eng, Keisuke Goda PhD, Daisuke Kudo MD, PhD, Tatsuhiko Arafune PhD, Toshikatsu Washio D.Eng, Teiji Tominaga MD, PhD, Atsuhiro Nakagawa, Kiyonobu Ohtani, Keisuke Goda, Daisuke Kudo, Tatsuhiko Arafune, Toshikatsu Washio, Teiji Tominaga |
Editors |
Beng-Ti Ang |
Abstract |
Purpose Primary blast-induced traumatic brain injury (bTBI) is the least understood of the four phases of blast injury. Distant injury induced by the blast wave, on the opposite side from the wave entry, is not well understood. This study investigated the mechanism of distant injury in bTBI. Materials and Methods Eight 8-week-old male Sprague-Dawley rats were divided into two groups: group 1 served as the control group and did not receive any shock wave (SW) exposure; group 2 was exposed to SWs (12.5 ± 2.5 MPa). Propagation of SWs within a brain phantom was evaluated by visualization, pressure measurement, and numerical simulation. Results Intracerebral hemorrhage near the ignition site and elongation of the distant nucleus were observed, despite no apparent damage between the two locations in the animal experiment. Visualization, pressure measurement, and numerical simulation indicated the presence of complex wave dynamics accompanying a sudden increase in pressure, followed by negative pressure in the phantom experiment. Conclusion A local increase in pressure above the threshold caused by interference of reflection and rarefaction waves in the vicinity of the brain-skull surface may cause distant injury in bTBI. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 22% |
Student > Ph. D. Student | 3 | 17% |
Student > Bachelor | 2 | 11% |
Professor | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Other | 1 | 6% |
Unknown | 4 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 22% |
Neuroscience | 3 | 17% |
Engineering | 3 | 17% |
Nursing and Health Professions | 2 | 11% |
Chemistry | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 22% |