Chapter title |
Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism
|
---|---|
Chapter number | 3 |
Book title |
Pharmacology of Mitochondria
|
Published in |
Handbook of experimental pharmacology, July 2016
|
DOI | 10.1007/164_2016_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-957311-3, 978-3-31-957313-7
|
Authors |
Sepuri, Naresh Babu V, Tammineni, Prasad, Mohammed, Fareed, Paripati, Arunkumar, Naresh Babu V. Sepuri, Prasad Tammineni, Fareed Mohammed, Arunkumar Paripati |
Abstract |
Noncanonical functions of several nuclear transcription factors in the mitochondria have been gaining exceptional traction over the years. These transcription factors include nuclear hormone receptors like estrogen, glucocorticoid, and thyroid hormone receptors: p53, IRF3, STAT3, STAT5, CREB, NF-kB, and MEF-2D. Mitochondria-localized nuclear transcription factors regulate mitochondrial processes like apoptosis, respiration and mitochondrial transcription albeit being nuclear in origin and having nuclear functions. Hence, the cell permits these multi-stationed transcription factors to orchestrate and fine-tune cellular metabolism at various levels of operation. Despite their ubiquitous distribution in different subcompartments of mitochondria, their targeting mechanism is poorly understood. Here, we review the current status of mitochondria-localized transcription factors and discuss the possible targeting mechanism besides the functional interplay between these factors. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 25% |
Student > Master | 4 | 17% |
Student > Ph. D. Student | 4 | 17% |
Student > Doctoral Student | 1 | 4% |
Professor | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 42% |
Neuroscience | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Agricultural and Biological Sciences | 1 | 4% |
Other | 0 | 0% |
Unknown | 9 | 38% |