Chapter title |
Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
|
---|---|
Chapter number | 117 |
Book title |
Pharmacology of Mitochondria
|
Published in |
Handbook of experimental pharmacology, January 2016
|
DOI | 10.1007/164_2016_117 |
Pubmed ID | |
Book ISBNs |
978-3-31-957311-3, 978-3-31-957313-7
|
Authors |
Hiroko P. Indo, Clare L. Hawkins, Ikuo Nakanishi, Ken-ichiro Matsumoto, Hirofumi Matsui, Shigeaki Suenaga, Michael J. Davies, Daret K. St Clair, Toshihiko Ozawa, Hideyuki J. Majima |
Abstract |
Mitochondria are a major source of intracellular energy and reactive oxygen species in cells, but are also increasingly being recognized as a controller of cell death. Here, we review evidence of signal transduction control by mitochondrial superoxide generation via the nuclear factor-κB (NF-κB) and GATA signaling pathways. We have also reviewed the effects of ROS on the activation of MMP and HIF. There is significant evidence to support the hypothesis that mitochondrial superoxide can initiate signaling pathways following transport into the cytosol. In this study, we provide evidence of TATA signal transductions by mitochondrial superoxide. Oxidative phosphorylation via the electron transfer chain, glycolysis, and generation of superoxide from mitochondria could be important factors in regulating signal transduction, cellular homeostasis, and cell death. |
Mendeley readers
Geographical breakdown
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Spain | 1 | 6% |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 25% |
Student > Bachelor | 3 | 19% |
Student > Doctoral Student | 2 | 13% |
Professor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Other | 3 | 19% |
Readers by discipline | Count | As % |
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Physics and Astronomy | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 2 | 13% |