| Chapter title |
The MRL Model: An Invaluable Tool in Studies of Autoimmunity-Brain Interactions.
|
|---|---|
| Chapter number | 14 |
| Book title |
Psychoneuroimmunology
|
| Published in |
Methods in molecular biology, August 2012
|
| DOI | 10.1007/978-1-62703-071-7_14 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-070-0, 978-1-62703-071-7
|
| Authors |
Boris Sakić, Sakić, Boris |
| Abstract |
The link between systemic autoimmunity, brain pathology, and aberrant behavior is still largely unexplored field of biomedical science. Accumulating evidence points to causal relationships between immune factors, neurodegeneration, and neuropsychiatric manifestations. By documenting autoimmunity-associated neuronal degeneration and cytotoxicity of the cerebrospinal fluid from disease-affected subjects, the murine MRL model had shown high validity in revealing principal pathogenic circuits. In addition, unlike any other autoimmune strain, MRL mice produce antibodies commonly found in patients suffering from lupus and other autoimmune disorders. This review highlights importance of the MRL model as an indispensible preparation in understanding the links between immune system and brain function. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 40% |
| Other | 2 | 40% |
| Student > Bachelor | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 40% |
| Immunology and Microbiology | 1 | 20% |
| Arts and Humanities | 1 | 20% |
| Unknown | 1 | 20% |