| Chapter title |
Exploring the diagnostic potential of immune biomarker coexpression in gulf war illness.
|
|---|---|
| Chapter number | 8 |
| Book title |
Psychoneuroimmunology
|
| Published in |
Methods in molecular biology, August 2012
|
| DOI | 10.1007/978-1-62703-071-7_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-070-0, 978-1-62703-071-7
|
| Authors |
Broderick G, Fletcher MA, Gallagher M, Barnes Z, Vernon SD, Klimas NG, Gordon Broderick, Mary Ann Fletcher, Michael Gallagher, Zachary Barnes, Suzanne D. Vernon, Nancy G. Klimas, Broderick, Gordon, Fletcher, Mary Ann, Gallagher, Michael, Barnes, Zachary, Vernon, Suzanne D., Klimas, Nancy G. |
| Abstract |
Complex disorders like Gulf War Illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the coexpression of multiple markers measured in response to a challenge. We demonstrate the practical application of such an approach using an example where blood was collected from 26 GWI, 13 healthy control subjects, and 9 unhealthy controls with Chronic Fatigue at three points during a graded exercise challenge. A 3-way multivariate projection model based on 12 markers of endocrine and immune function was constructed using a training set of n = 10 GWI and n = 11 healthy controls. These groups were separated almost completely on the basis of two coexpression patterns. In a separate test set these same features allowed for discrimination of new GWI subjects (n = 16) from unhealthy (n = 9) and healthy control subjects with a sensitivity of 70% and a specificity of 90%. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 75% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 12% |
| Unknown | 15 | 88% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 18% |
| Professor | 3 | 18% |
| Student > Doctoral Student | 2 | 12% |
| Other | 1 | 6% |
| Librarian | 1 | 6% |
| Other | 3 | 18% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 3 | 18% |
| Medicine and Dentistry | 3 | 18% |
| Immunology and Microbiology | 1 | 6% |
| Biochemistry, Genetics and Molecular Biology | 1 | 6% |
| Agricultural and Biological Sciences | 1 | 6% |
| Other | 1 | 6% |
| Unknown | 7 | 41% |