Chapter title |
Tumor Microenvironment
|
---|---|
Chapter number | 16 |
Book title |
Tumor Microenvironment
|
Published in |
Advances in experimental medicine and biology, June 2016
|
DOI | 10.1007/978-3-319-26666-4_16 |
Pubmed ID | |
Book ISBNs |
978-3-31-926664-0, 978-3-31-926666-4
|
Authors |
Hong, Cho Rong, Wang, Jingli, Hicks, Kevin O, Hay, Michael P, Hicks, Kevin O., Hay, Michael P., Cho Rong Hong, Jingli Wang, Kevin O. Hicks, Michael P. Hay |
Abstract |
An evolution in radiotherapy practice is leading to greater use of stereotactic body radiotherapy (SBRT), raising the prospect of increased hypoxic cell radioresistance. New clinical interest in nitroimidazole radiosensitisers, combined with appropriate biomarkers, signals a revival for radiosensitisers in the context of SBRT. Our interest in modifiers of radiation therapy led us to revisit this area and we have identified a new class of nitroimidazole radiosensitiser. We have developed an abbreviated screening protocol suitable for an academic drug discovery laboratory which allows expeditious triage of compounds with poor physicochemical and in vitro properties and combines in vitro radiosensitisation data with tumour pharmacokinetic data to efficiently select candidates for further evaluation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 31% |
Researcher | 3 | 19% |
Student > Bachelor | 2 | 13% |
Student > Ph. D. Student | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 13% |
Unknown | 2 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 4 | 25% |
Medicine and Dentistry | 4 | 25% |
Chemistry | 2 | 13% |
Physics and Astronomy | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Other | 2 | 13% |
Unknown | 2 | 13% |