Chapter title |
Tumor Microenvironment
|
---|---|
Chapter number | 4 |
Book title |
Tumor Microenvironment
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-26666-4_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-926664-0, 978-3-31-926666-4
|
Authors |
Brady, Lauren K, Popov, Vladimir, Koumenis, Constantinos, Lauren K. Brady, Vladimir Popov, Constantinos Koumenis, Brady, Lauren K. |
Abstract |
Global gene expression analysis is a powerful method for identifying biological networks and regulatory mechanisms that govern cellular or tissue-level responses to physiologic stress. In the context of tumor biology, differential gene expression studies have provided information about the growth, aggressiveness, prognosis, and therapeutic response of tumors in patients. Scientists are using these valuable data to investigate pathways that can be targeted therapeutically with the goal of improving patient outcome. RNA sequencing enables nucleotide resolution of expression of whole transcriptomes, but arrives with a new set of challenges surrounding the management and analysis of large datasets. This chapter aims to review technical advancements to current methods for isolating high-quality RNA for sequencing studies directly from hypoxic tissues and introduces select widely used applications for gene expression analyses of next-generation sequencing data. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 14% |
Unknown | 6 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 2 | 29% |
Student > Ph. D. Student | 1 | 14% |
Student > Bachelor | 1 | 14% |
Researcher | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 29% |
Agricultural and Biological Sciences | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 3 | 43% |