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Gapmers

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Cover of 'Gapmers'

Table of Contents

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    Book Overview
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    Chapter 1 Invention and Early History of Gapmers
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    Chapter 2 Development and Clinical Applications of Antisense Oligonucleotide Gapmers
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    Chapter 3 Knocking Down Long Noncoding RNAs Using Antisense Oligonucleotide Gapmers
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    Chapter 4 Development of Antisense Oligonucleotide Gapmers for the Treatment of Huntington’s Disease
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    Chapter 5 Development of Antisense Oligonucleotide Gapmers for the Treatment of Dyslipidemia and Lipodystrophy
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    Chapter 6 Inotersen for the Treatment of Hereditary Transthyretin Amyloidosis
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    Chapter 7 Degradation of Toxic RNA in Myotonic Dystrophy Using Gapmer Antisense Oligonucleotides
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    Chapter 8 DNA–RNA Heteroduplex Oligonucleotide for Highly Efficient Gene Silencing
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    Chapter 9 Tips for Successful lncRNA Knockdown Using Gapmers
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    Chapter 10 Calcium-Mediated In Vitro Transfection Technique of Oligonucleotides with Broad Chemical Modification Compatibility
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    Chapter 11 Evaluating the Knockdown Activity of MALAT1 ENA Gapmers In Vitro
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    Chapter 12 Albumin-Binding Fatty Acid–Modified Gapmer Antisense Oligonucleotides for Modulation of Pharmacokinetics
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    Chapter 13 The Use of Gapmers for In Vivo Suppression of Hepatic mRNA Targets
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    Chapter 14 Development of LNA Gapmer Oligonucleotide-Based Therapy for ALS/FTD Caused by the C9orf72 Repeat Expansion
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    Chapter 15 Targeted Gene Silencing in Malignant Hematolymphoid Cells Using GapmeR
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    Chapter 16 Gapmer Antisense Oligonucleotides to Selectively Suppress the Mutant Allele in COL6A Genes in Dominant Ullrich Congenital Muscular Dystrophy
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    Chapter 17 Detection of Locked Nucleic Acid Gapmers from Mouse Muscle Samples Using ELISA
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Title
Gapmers
Published by
Springer US, January 2020
DOI 10.1007/978-1-0716-0771-8
ISBNs
978-1-07-160770-1, 978-1-07-160771-8
Editors

Toshifumi Yokota, Rika Maruyama

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