| Chapter title |
Biology of the Sertoli Cell in the Fetal, Pubertal, and Adult Mammalian Testis.
|
|---|---|
| Chapter number | 9 |
| Book title |
Molecular Mechanisms of Cell Differentiation in Gonad Development
|
| Published in |
Results and problems in cell differentiation, June 2016
|
| DOI | 10.1007/978-3-319-31973-5_9 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-931971-1, 978-3-31-931973-5
|
| Authors |
Katarzyna Chojnacka, Marta Zarzycka, Dolores D. Mruk Ph.D., Dolores D. Mruk |
| Editors |
Rafal P. Piprek |
| Abstract |
A healthy man typically produces between 50 × 10(6) and 200 × 10(6) spermatozoa per day by spermatogenesis; in the absence of Sertoli cells in the male gonad, this individual would be infertile. In the adult testis, Sertoli cells are sustentacular cells that support germ cell development by secreting proteins and other important biomolecules that are essential for germ cell survival and maturation, establishing the blood-testis barrier, and facilitating spermatozoa detachment at spermiation. In the fetal testis, on the other hand, pre-Sertoli cells form the testis cords, the future seminiferous tubules. However, the role of pre-Sertoli cells in this process is much less clear than the function of Sertoli cells in the adult testis. Within this framework, we provide an overview of the biology of the fetal, pubertal, and adult Sertoli cell, highlighting relevant cell biology studies that have expanded our understanding of mammalian spermatogenesis. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 19% |
| Student > Doctoral Student | 5 | 14% |
| Student > Ph. D. Student | 4 | 11% |
| Researcher | 3 | 8% |
| Other | 2 | 6% |
| Other | 6 | 17% |
| Unknown | 9 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 9 | 25% |
| Agricultural and Biological Sciences | 6 | 17% |
| Medicine and Dentistry | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Nursing and Health Professions | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 11 | 31% |