Chapter title |
Evaluation of Biocompatibility Using In Vitro Methods: Interpretation and Limitations.
|
---|---|
Chapter number | 111 |
Book title |
Tissue Engineering III: Cell - Surface Interactions for Tissue Culture
|
Published in |
Advances in biochemical engineering biotechnology, December 2011
|
DOI | 10.1007/10_2011_111 |
Pubmed ID | |
Book ISBNs |
978-3-64-228281-2, 978-3-64-228282-9
|
Authors |
Bruinink A, Luginbuehl R, Arie Bruinink, Reto Luginbuehl, Bruinink, Arie, Luginbuehl, Reto |
Abstract |
The in vitro biocompatibility of novel materials has to be proven before a material can be used as component of a medical device. This must be done in cell culture tests according to internationally recognized standard protocols. Subsequently, preclinical and clinical tests must be performed to verify the safety of the new material and device. The present chapter focuses on the first step, the in vitro testing according to ISO 10993-5, and critically discusses its limited significance. Alternative strategies and a brief overview of activities to improve the current in vitro tests are presented in the concluding section. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 1% |
Switzerland | 1 | 1% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 19% |
Student > Bachelor | 13 | 17% |
Student > Master | 9 | 12% |
Researcher | 7 | 9% |
Other | 5 | 6% |
Other | 7 | 9% |
Unknown | 22 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 10 | 13% |
Medicine and Dentistry | 9 | 12% |
Agricultural and Biological Sciences | 7 | 9% |
Chemistry | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Other | 12 | 15% |
Unknown | 27 | 35% |