Chapter title |
Chemotaxis
|
---|---|
Chapter number | 24 |
Book title |
Chemotaxis
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3480-5_24 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3478-2, 978-1-4939-3480-5
|
Authors |
Martínez-Muñoz, Laura, Rodríguez-Frade, José Miguel, Mellado, Mario, Laura Martínez-Muñoz, José Miguel Rodríguez-Frade, Mario Mellado |
Abstract |
Since the first reports on chemokine function, much information has been generated on the implications of these molecules in numerous physiological and pathological processes, as well as on the signaling events activated through their binding to receptors. As is the case for other G protein-coupled receptors, chemokine receptors are not isolated entities that are activated following ligand binding; rather, they are found as dimers and/or higher order oligomers at the cell surface, even in the absence of ligands. These complexes form platforms that can be modified by receptor expression and ligand levels, indicating that they are dynamic structures. The analysis of the conformations adopted by these receptors at the membrane and their dynamics is thus crucial for a complete understanding of the function of the chemokines. We focus here on the methodology insights of new techniques, such as those based on resonance energy transfer for the analysis of chemokine receptor conformations in living cells. |
X Demographics
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 50% |
Researcher | 1 | 17% |
Student > Doctoral Student | 1 | 17% |
Student > Master | 1 | 17% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 2 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 17% |
Nursing and Health Professions | 1 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Unknown | 1 | 17% |