| Chapter title |
DNA methylation screening and analysis.
|
|---|---|
| Chapter number | 24 |
| Book title |
Developmental Toxicology
|
| Published in |
Methods in molecular biology, April 2012
|
| DOI | 10.1007/978-1-61779-867-2_24 |
| Pubmed ID | |
| Book ISBNs |
978-1-61779-866-5, 978-1-61779-867-2
|
| Authors |
Sant KE, Nahar MS, Dolinoy DC, Craig Harris, Jason M. Hansen, Karilyn E. Sant, Muna S. Nahar, Dana C. Dolinoy, Sant, Karilyn E., Nahar, Muna S., Dolinoy, Dana C. |
| Abstract |
DNA methylation is an epigenetic form of gene regulation that is universally important throughout the life course, especially during in utero and postnatal development. DNA methylation aids in cell cycle regulation and cellular differentiation processes. Previous studies have demonstrated that DNA methylation profiles may be altered by diet and the environment, and that these profiles are especially vulnerable during development. Thus, it is important to understand the role of DNA methylation in developmental governance and subsequent disease progression. A variety of molecular methods exist to assay for global, gene-specific, and epigenome-wide methylation. Here we describe these methods and discuss their relative strengths and limitations. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 122 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 21% |
| Student > Ph. D. Student | 23 | 19% |
| Student > Bachelor | 19 | 16% |
| Student > Master | 14 | 11% |
| Student > Doctoral Student | 7 | 6% |
| Other | 16 | 13% |
| Unknown | 17 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 34 | 28% |
| Agricultural and Biological Sciences | 28 | 23% |
| Medicine and Dentistry | 9 | 7% |
| Nursing and Health Professions | 5 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 4% |
| Other | 18 | 15% |
| Unknown | 23 | 19% |