Chapter title |
Twin-Arginine Protein Translocation
|
---|---|
Chapter number | 7 |
Book title |
Protein and Sugar Export and Assembly in Gram-positive Bacteria
|
Published in |
Current topics in microbiology and immunology, April 2016
|
DOI | 10.1007/82_2016_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-956012-0, 978-3-31-956014-4
|
Authors |
Goosens, Vivianne J, van Dijl, Jan Maarten, Goosens, Vivianne J., Vivianne J. Goosens, Jan Maarten van Dijl |
Abstract |
Twin-arginine protein translocation systems (Tat) translocate fully folded and co-factor-containing proteins across biological membranes. In this review, we focus on the Tat pathway of Gram-positive bacteria. The minimal Tat pathway is composed of two components, namely a TatA and TatC pair, which are often complemented with additional TatA-like proteins. We provide overviews of our current understanding of Tat pathway composition and mechanistic aspects related to Tat-dependent cargo protein translocation. This includes Tat pathway flexibility, requirements for the correct folding and incorporation of co-factors in cargo proteins and the functions of known cargo proteins. Tat pathways of several Gram-positive bacteria are discussed in detail, with emphasis on the Tat pathway of Bacillus subtilis. We discuss both shared and unique features of the different Gram-positive bacterial Tat pathways. Lastly, we highlight topics for future research on Tat, including the development of this protein transport pathway for the biotechnological secretion of high-value proteins and its potential applicability as an antimicrobial drug target in pathogens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 23% |
Student > Master | 6 | 23% |
Student > Bachelor | 4 | 15% |
Other | 2 | 8% |
Researcher | 2 | 8% |
Other | 2 | 8% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 31% |
Agricultural and Biological Sciences | 7 | 27% |
Immunology and Microbiology | 3 | 12% |
Veterinary Science and Veterinary Medicine | 1 | 4% |
Neuroscience | 1 | 4% |
Other | 2 | 8% |
Unknown | 4 | 15% |