Chapter title |
Type VII Secretion Systems in Gram-Positive Bacteria
|
---|---|
Chapter number | 5015 |
Book title |
Protein and Sugar Export and Assembly in Gram-positive Bacteria
|
Published in |
Current topics in microbiology and immunology, January 2015
|
DOI | 10.1007/82_2015_5015 |
Pubmed ID | |
Book ISBNs |
978-3-31-956012-0, 978-3-31-956014-4
|
Authors |
Daria Bottai, Matthias I. Gröschel, Roland Brosch, Bottai, Daria, Gröschel, Matthias I., Brosch, Roland |
Editors |
Fabio Bagnoli, Rino Rappuoli |
Abstract |
Bacterial secretion systems are sophisticated molecular machines that fulfil a wide range of important functions, which reach from export/secretion of essential proteins or virulence factors to the implication in conjugation processes. In contrast to the widely distributed Sec and Twin Arginine Translocation (TAT) systems, the recently identified ESX/type VII systems show a more restricted distribution and are typical for mycobacteria and other high-GC Actinobacteria. Similarly, type VII-like secretion systems have been described in low-GC Gram-positive bacteria belonging to the phylum Firmicutes. While the most complex organization of type VII secretion systems currently known is found in slow-growing mycobacteria, which harbour up to 5 chromosomal-encoded systems (ESX-1 to ESX-5), much simpler organization is reported for type VII-like systems in Firmicutes. In this chapter, we describe common and divergent features of type VII- and type VII-like secretion pathways and also comment on their biological key roles, many of which are related to species-/genus-specific host-pathogen interactions and/or virulence mechanisms. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 16% |
Student > Ph. D. Student | 8 | 14% |
Student > Bachelor | 7 | 13% |
Student > Master | 7 | 13% |
Student > Doctoral Student | 5 | 9% |
Other | 7 | 13% |
Unknown | 13 | 23% |
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Immunology and Microbiology | 7 | 13% |
Nursing and Health Professions | 1 | 2% |
Environmental Science | 1 | 2% |
Other | 4 | 7% |
Unknown | 12 | 21% |