Chapter title |
Symptoms: Chemotherapy-Induced Peripheral Neuropathy
|
---|---|
Chapter number | 6 |
Book title |
Improving Outcomes for Breast Cancer Survivors
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-16366-6_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-916365-9, 978-3-31-916366-6
|
Authors |
Bryan P. Schneider, Dawn L. Hershman, Charles Loprinzi |
Abstract |
Chemotherapy-induced peripheral neuropathy (CIPN) is a problematic, treatment-induced toxicity that has the potential to impact quality of life and limit the doses of curative intent therapy. This therapy-induced side effect is one of the most troublesome in oncology clinical practices, considering the morbidity, the frequency, and the potential irreversibility of this problem. Patients with breast cancer are particularly impacted by this side effect as multiple agents commonly used for this disease can cause neuropathy. In this chapter, we provide an overview of CIPN, including: clinical predictors, frequency, and its impact on quality of life. Further, we highlight the pathophysiology and review the literature to date for agents designed to prevent or treat CIPN. We also highlight the most important ongoing clinical and translational research questions that hope to help better predict and prevent this toxicity. This includes optimizing the methods of assessment, using host specific factors (Race and genetics) to predict those more likely to experience CIPN, and determining how CIPN might impact clinical decisions toward therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 65 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 17% |
Student > Master | 11 | 17% |
Student > Doctoral Student | 8 | 12% |
Student > Postgraduate | 5 | 8% |
Researcher | 4 | 6% |
Other | 11 | 17% |
Unknown | 16 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 11 | 17% |
Medicine and Dentistry | 8 | 12% |
Neuroscience | 7 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Agricultural and Biological Sciences | 3 | 5% |
Other | 11 | 17% |
Unknown | 21 | 32% |