| Chapter title |
microRNA: Basic Science
|
|---|---|
| Chapter number | 11 |
| Book title |
microRNA: Basic Science
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-3-319-22380-3_11 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922379-7, 978-3-31-922380-3
|
| Authors |
Caravia, Xurde M, López-Otín, Carlos, Xurde M. Caravia, Carlos López-Otín |
| Abstract |
Aging is a biological process characterized by the progressive deterioration of physiological functions that occurs through the accumulation of macromolecular and cellular damage. This phenomenon impairs tissue function and is a risk factor for many disorders including cardiovascular disease, neurodegenerative disorders, and cancer. A recent study has enumerated nine cellular and molecular hallmarks that represent common denominators of aging and together determine the aging phenotype, highlighting the concept of aging plasticity. Among the multiple molecular mechanisms which may contribute to aging modulation, microRNAs (miRNAs) are raising enormous interest due to their ability to affect all the "Hallmarks of Aging." In this chapter, we will focus on the description of the diverse functional roles of geromiRs, the large and growing subgroup of miRNAs implicated in aging. We will also address the molecular mechanisms underlying miRNA function in aging and discuss potential strategies for managing aging and extending longevity based on geromiR modulation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 28% |
| Student > Ph. D. Student | 6 | 19% |
| Student > Bachelor | 3 | 9% |
| Professor | 2 | 6% |
| Student > Master | 2 | 6% |
| Other | 3 | 9% |
| Unknown | 7 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 11 | 34% |
| Agricultural and Biological Sciences | 4 | 13% |
| Medicine and Dentistry | 4 | 13% |
| Neuroscience | 2 | 6% |
| Social Sciences | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 8 | 25% |