| Chapter title |
microRNA: Basic Science
|
|---|---|
| Chapter number | 4 |
| Book title |
microRNA: Basic Science
|
| Published in |
Advances in experimental medicine and biology, August 2016
|
| DOI | 10.1007/978-3-319-22380-3_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-922379-7, 978-3-31-922380-3
|
| Authors |
Gaetano Santulli, Santulli, Gaetano |
| Abstract |
Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are the main cell types within the vasculature. We describe here how microRNAs (miRs)-noncoding RNAs that can regulate gene expression via translational repression and/or post-transcriptional degradation-distinctively modulate EC and VSMC function in physiology and disease. In particular, the specific roles of miR-126 and miR-143/145, master regulators of EC and VSMC function, respectively, are deeply explored. We also describe the mechanistic role of miRs in the regulation of the pathophysiology of key cardiovascular processes including angiogenesis, atherosclerosis, and in-stent restenosis post-angioplasty. Drawbacks of currently available therapeutic options are discussed, pointing at the challenges and potential clinical opportunities provided by miR-based treatments. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 40 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 23% |
| Researcher | 6 | 15% |
| Student > Master | 6 | 15% |
| Student > Doctoral Student | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 8 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 25% |
| Agricultural and Biological Sciences | 7 | 18% |
| Medicine and Dentistry | 6 | 15% |
| Nursing and Health Professions | 1 | 3% |
| Chemistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 14 | 35% |