Moretti, Rocco, Bender, Brian J, Allison, Brittany, Meiler, Jens, Rocco Moretti, Brian J. Bender, Brittany Allison, Jens Meiler, Bender, Brian J.
Editors
Barry L. Stoddard
Abstract
Proteins that bind small molecules (ligands) can be used as biosensors, signal modulators, and sequestering agents. When naturally occurring proteins for a particular target ligand are not available, artificial proteins can be computationally designed. We present a protocol based on RosettaLigand to redesign an existing protein pocket to bind a target ligand. Starting with a protein structure and the structure of the ligand, Rosetta can optimize both the placement of the ligand in the pocket and the identity and conformation of the surrounding sidechains, yielding proteins that bind the target compound.
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2022.
All research outputs
#6,912,452
of 22,668,244 outputs
Outputs from Methods in molecular biology
#2,072
of 13,037 outputs
Outputs of similar age
#112,008
of 393,064 outputs
Outputs of similar age from Methods in molecular biology
#248
of 1,468 outputs
Altmetric has tracked 22,668,244 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 13,037 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,064 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1,468 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.
