Chapter title |
Diagnosis and Management of Hereditary Sarcoma.
|
---|---|
Chapter number | 10 |
Book title |
Rare Hereditary Cancers
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, April 2016
|
DOI | 10.1007/978-3-319-29998-3_10 |
Pubmed ID | |
Book ISBNs |
978-3-31-929996-9, 978-3-31-929998-3
|
Authors |
David M. Thomas, Mandy L. Ballinger, Thomas, David M, Ballinger, Mandy L, Thomas, David M., Ballinger, Mandy L. |
Editors |
Gabriella Pichert, Chris Jacobs |
Abstract |
Sarcomas are rare and heterogeneous diseases that affect a younger population than most epithelial cancers. Epidemiologic studies suggest a strong genetic component to sarcomas, and many familial cancer syndromes have been described, in which sarcomas are a feature. The best known of these are the Li-Fraumeni and retinoblastoma syndromes, study of which has been pivotal to elucidating the molecular basis for the cell response to DNA damage and the cell division. Although much has been learnt about cancer biology from the study of sarcoma families, in general clinical management of increased sarcoma risk has lagged behind other cancer predisposition syndromes. With the advent of genomic tools for genetic testing, it is likely that a substantial fraction of sarcoma patients will be identified as carriers of known risk alleles. The translation of this knowledge into effective risk management programs and cancer treatments will be essential to changes in routine clinical practice. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 4 | 24% |
Student > Bachelor | 3 | 18% |
Student > Postgraduate | 3 | 18% |
Professor | 2 | 12% |
Lecturer > Senior Lecturer | 1 | 6% |
Other | 3 | 18% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 41% |
Nursing and Health Professions | 3 | 18% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Economics, Econometrics and Finance | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 18% |