Chapter title |
Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease
|
---|---|
Chapter number | 5 |
Book title |
Growth Factors and Cytokines in Skeletal Muscle Development, Growth, Regeneration and Disease
|
Published in |
Advances in experimental medicine and biology, March 2016
|
DOI | 10.1007/978-3-319-27511-6_5 |
Pubmed ID | |
Book ISBNs |
978-3-31-927509-3, 978-3-31-927511-6
|
Authors |
Chen, Justin L, Colgan, Timothy D, Walton, Kelly L, Gregorevic, Paul, Harrison, Craig A, Justin L. Chen, Timothy D. Colgan, Kelly L. Walton, Paul Gregorevic, Craig A. Harrison, Chen, Justin L., Colgan, Timothy D., Walton, Kelly L., Harrison, Craig A. |
Editors |
Jason White, Gayle Smythe |
Abstract |
Skeletal muscle possesses remarkable ability to change its size and force-producing capacity in response to physiological stimuli. Impairment of the cellular processes that govern these attributes also affects muscle mass and function in pathological conditions. Myostatin, a member of the TGF-β family, has been identified as a key regulator of muscle development, and adaptation in adulthood. In muscle, myostatin binds to its type I (ALK4/5) and type II (ActRIIA/B) receptors to initiate Smad2/3 signalling and the regulation of target genes that co-ordinate the balance between protein synthesis and degradation. Interestingly, evidence is emerging that other TGF-β proteins act in concert with myostatin to regulate the growth and remodelling of skeletal muscle. Consequently, dysregulation of TGF-β proteins and their associated signalling components is increasingly being implicated in muscle wasting associated with chronic illness, ageing, and inactivity. The growing understanding of TGF-β biology in muscle, and its potential to advance the development of therapeutics for muscle-related conditions is reviewed here. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 13% |
Taiwan | 1 | 7% |
United Kingdom | 1 | 7% |
Unknown | 11 | 73% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 67% |
Scientists | 4 | 27% |
Practitioners (doctors, other healthcare professionals) | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 23% |
Student > Master | 6 | 12% |
Student > Bachelor | 5 | 10% |
Other | 4 | 8% |
Researcher | 4 | 8% |
Other | 4 | 8% |
Unknown | 17 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 11 | 21% |
Medicine and Dentistry | 9 | 17% |
Agricultural and Biological Sciences | 8 | 15% |
Mathematics | 1 | 2% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 8% |
Unknown | 18 | 35% |