Chapter title |
Novel Biomarkers in the Continuum of Breast Cancer
|
---|---|
Chapter number | 7 |
Book title |
Novel Biomarkers in the Continuum of Breast Cancer
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-22909-6_7 |
Pubmed ID | |
Book ISBNs |
978-3-31-922908-9, 978-3-31-922909-6
|
Authors |
Beca, Francisco, Polyak, Kornelia, Francisco Beca, Kornelia Polyak |
Abstract |
Intratumor heterogeneity is the main obstacle to effective cancer treatment and personalized medicine. Both genetic and epigenetic sources of intratumor heterogeneity are well recognized and several technologies have been developed for their characterization. With the technological advances in recent years, investigators are now elucidating intratumor heterogeneity at the single cell level and in situ. However, translating the accumulated knowledge about intratumor heterogeneity to clinical practice has been slow. We are certain that better understanding of the composition and evolution of tumors during disease progression and treatment will improve cancer diagnosis and the design of therapies. Here we review some of the most important considerations related to intratumor heterogeneity. We discuss both genetic and epigenetic sources of intratumor heterogeneity and review experimental approaches that are commonly used to quantify it. We also discuss the impact of intratumor heterogeneity on cancer diagnosis and treatment and share our perspectives on the future of this field. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 102 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 20% |
Researcher | 12 | 12% |
Student > Bachelor | 12 | 12% |
Student > Master | 11 | 11% |
Student > Postgraduate | 7 | 7% |
Other | 15 | 15% |
Unknown | 25 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 25 | 25% |
Medicine and Dentistry | 16 | 16% |
Agricultural and Biological Sciences | 10 | 10% |
Engineering | 6 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 12 | 12% |
Unknown | 30 | 29% |