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Novel Biomarkers in the Continuum of Breast Cancer

Overview of attention for book
Attention for Chapter 1: Novel Biomarkers in the Continuum of Breast Cancer
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Citations

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100 Mendeley
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Chapter title
Novel Biomarkers in the Continuum of Breast Cancer
Chapter number 1
Book title
Novel Biomarkers in the Continuum of Breast Cancer
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/978-3-319-22909-6_1
Pubmed ID
Book ISBNs
978-3-31-922908-9, 978-3-31-922909-6
Authors

Walsh, Michael F, Nathanson, Katherine L, Couch, Fergus J, Offit, Kenneth, Michael F. Walsh, Katherine L. Nathanson, Fergus J. Couch, Kenneth Offit

Abstract

Clinical risk assessment for cancer predisposition includes a three-generation pedigree and physical examination to identify inherited syndromes. Additionally genetic and genomic biomarkers may identify individuals with a constitutional basis for their disease that may not be evident clinically. Genomic biomarker testing may detect molecular variations in single genes, panels of genes, or entire genomes. The strength of evidence for the association of a genomic biomarker with disease risk may be weak or strong. The factors contributing to clinical validity and utility of genomic biomarkers include functional laboratory analyses and genetic epidemiologic evidence. Genomic biomarkers may be further classified as low, moderate or highly penetrant based on the likelihood of disease. Genomic biomarkers for breast cancer are comprised of rare highly penetrant mutations of genes such as BRCA1 or BRCA2, moderately penetrant mutations of genes such as CHEK2, as well as more common genomic variants, including single nucleotide polymorphisms, associated with modest effect sizes. When applied in the context of appropriate counseling and interpretation, identification of genomic biomarkers of inherited risk for breast cancer may decrease morbidity and mortality, allow for definitive prevention through assisted reproduction, and serve as a guide to targeted therapy .

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Unknown 99 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 21 21%
Researcher 13 13%
Student > Master 10 10%
Student > Ph. D. Student 9 9%
Student > Doctoral Student 5 5%
Other 14 14%
Unknown 28 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 19%
Agricultural and Biological Sciences 14 14%
Medicine and Dentistry 13 13%
Nursing and Health Professions 4 4%
Unspecified 4 4%
Other 14 14%
Unknown 32 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2016.
All research outputs
#13,972,009
of 22,856,968 outputs
Outputs from Advances in experimental medicine and biology
#2,008
of 4,950 outputs
Outputs of similar age
#199,630
of 393,637 outputs
Outputs of similar age from Advances in experimental medicine and biology
#177
of 443 outputs
Altmetric has tracked 22,856,968 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,950 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 393,637 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 443 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.