| Chapter title |
Genotyping of Frequent Mutations in Solid Tumors by PCR-Based Single-Base Extension and MassARRAY Analysis
|
|---|---|
| Chapter number | 9 |
| Book title |
Clinical Applications of PCR
|
| Published in |
Methods in molecular biology, February 2016
|
| DOI | 10.1007/978-1-4939-3360-0_9 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-3358-7, 978-1-4939-3360-0
|
| Authors |
Mondolfi, Alberto Paniz, Singh, Rajesh R., Alberto Paniz Mondolfi, Rajesh R. Singh |
| Editors |
Rajyalakshmi Luthra, Rajesh R. Singh, Keyur P. Patel |
| Abstract |
Over the last decade, cancer genome sequencing has revealed in detail the genomic landscapes of an increasing number of common solid human tumors. This has greatly impacted the clinical care of cancer patients based on the fact that many of these tumors exhibit activating mutations in driver genes that are prone to target therapy, largely impacting cancer management strategies. Genomic heterogeneity of tumors is becoming an increasingly recognized phenomenon relevant to genome-based medicine. Because a large number tumors may display several mutations at the same time, multiplexing has become the preferred approach to reveal the mutational landscape in patient samples and to better design a targeted approach to their illness. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 50% |
| Agricultural and Biological Sciences | 1 | 50% |