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Glucocorticoid Signaling

Overview of attention for book
Cover of 'Glucocorticoid Signaling'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Regulatory Actions of Glucocorticoid Hormones: From Organisms to Mechanisms
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    Chapter 2 Molecular Biology of Glucocorticoid Signaling.
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    Chapter 3 Mechanisms of Glucocorticoid-Regulated Gene Transcription.
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    Chapter 4 Clinical Perspective: What Do Addison and Cushing Tell Us About Glucocorticoid Action?
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    Chapter 5 Regulation of Glucose Homeostasis by Glucocorticoids
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    Chapter 6 How Do Glucocorticoids Regulate Lipid Metabolism?
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    Chapter 7 Glucocorticoids and Skeletal Muscle
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    Chapter 8 Glucocorticoid-Induced Osteoporosis
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    Chapter 9 Effects of Glucocorticoids in the Immune System
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    Chapter 10 Glucocorticoids and the Brain: Neural Mechanisms Regulating the Stress Response
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    Chapter 11 Glucocorticoid Regulation of Reproduction
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    Chapter 12 Glucocorticoids and the Lung
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    Chapter 13 Glucocorticoids and the Cardiovascular System
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    Chapter 14 Glucocorticoids and Cancer.
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    Chapter 15 Animal Models of Altered Glucocorticoid Signaling
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    Chapter 16 The Dehydrogenase Hypothesis.
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    Chapter 17 Conclusions and Future Directions.
Attention for Chapter 14: Glucocorticoids and Cancer.
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

news
2 news outlets
twitter
3 X users
wikipedia
1 Wikipedia page

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
160 Mendeley
Summary News X Wikipedia Dimensions citations
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Chapter title
Glucocorticoids and Cancer.
Chapter number 14
Book title
Glucocorticoid Signaling
Published in
Advances in experimental medicine and biology, January 2015
DOI 10.1007/978-1-4939-2895-8_14
Pubmed ID
26216001
Book ISBNs
978-1-4939-2894-1, 978-1-4939-2895-8
Authors

Pufall, Miles A, Miles A. Pufall, Pufall, Miles A.

Abstract

Unlike other steroid hormone receptors, the glucocorticoid receptor (GR) is not considered an oncogene. In breast cancer, the estrogen receptor (ER) drives cell growth, proliferation, and metastasis, and the androgen receptor (AR) plays a similar role in prostate cancer. Accordingly, treatment of these diseases has focused on blocking steroid hormone receptor function. In contrast, glucocorticoids (GCs) work through GR to arrest growth and induce apoptosis in lymphoid tissue. Glucocorticoids are amazingly effective in this role, and have been deployed as the cornerstone of lymphoid cancer treatment for decades. Unfortunately, not all patients respond to GCs and dosage is restricted by immediate and long term side effects. In this chapter we review the treatment protocols that employ glucocorticoids as a curative agent, elaborate on what is known about their mechanism of action in these cancers, and also summarize the palliative uses of glucocorticoids for other cancers.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 160 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 160 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 26 16%
Student > Master 21 13%
Student > Bachelor 16 10%
Researcher 15 9%
Student > Doctoral Student 6 4%
Other 15 9%
Unknown 61 38%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 28 18%
Medicine and Dentistry 20 13%
Agricultural and Biological Sciences 12 8%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Neuroscience 4 3%
Other 22 14%
Unknown 66 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2023.
All research outputs
#1,810,049
of 25,550,333 outputs
Outputs from Advances in experimental medicine and biology
#241
of 5,263 outputs
Outputs of similar age
#23,947
of 360,433 outputs
Outputs of similar age from Advances in experimental medicine and biology
#14
of 272 outputs
Altmetric has tracked 25,550,333 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,263 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,433 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 272 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.

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