Chapter title |
Predicting Subcellular Localization of Proteins by Bioinformatic Algorithms
|
---|---|
Chapter number | 5006 |
Book title |
Protein and Sugar Export and Assembly in Gram-positive Bacteria
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/82_2015_5006 |
Pubmed ID | |
Book ISBNs |
978-3-31-956012-0, 978-3-31-956014-4
|
Authors |
Henrik Nielsen, Nielsen, Henrik |
Abstract |
When predicting the subcellular localization of proteins from their amino acid sequences, there are basically three approaches: signal-based, global property-based, and homology-based. Each of these has its advantages and drawbacks, and it is important when comparing methods to know which approach was used. Various statistical and machine learning algorithms are used with all three approaches, and various measures and standards are employed when reporting the performances of the developed methods. This chapter presents a number of available methods for prediction of sorting signals and subcellular localization, but rather than providing a checklist of which predictors to use, it aims to function as a guide for critical assessment of prediction methods. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United States | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
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Student > Master | 5 | 23% |
Student > Postgraduate | 4 | 18% |
Student > Ph. D. Student | 4 | 18% |
Student > Bachelor | 2 | 9% |
Researcher | 2 | 9% |
Other | 2 | 9% |
Unknown | 3 | 14% |
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Computer Science | 3 | 14% |
Immunology and Microbiology | 1 | 5% |
Engineering | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 18% |