| Chapter title |
Prospective Advances in Circular RNA Investigation
|
|---|---|
| Chapter number | 28 |
| Book title |
Circular RNAs
|
| Published in |
Advances in experimental medicine and biology, September 2018
|
| DOI | 10.1007/978-981-13-1426-1_28 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-131425-4, 978-9-81-131426-1
|
| Authors |
Siti Aishah Sulaiman, Nor Azian Abdul Murad, Ezanee Azlina Mohamad Hanif, Nadiah Abu, Rahman Jamal, Sulaiman, Siti Aishah, Abdul Murad, Nor Azian, Mohamad Hanif, Ezanee Azlina, Abu, Nadiah, Jamal, Rahman |
| Abstract |
circRNAs have emerged as one of the key regulators in many cellular mechanisms and pathogenesis of diseases. However, with the limited knowledge and current technologies for circRNA investigations, there are several challenges that need to be addressed for. These include challenges in understanding the regulation of circRNA biogenesis, experimental designs, and sample preparations to characterize the circRNAs in diseases as well as the bioinformatics pipelines and algorithms. In this chapter, we discussed the above challenges and possible strategies to overcome those limitations. We also addressed the differences between the existing applications and technologies to study the circRNAs in diseases. By addressing these challenges, further understanding of circRNAs roles and regulations as well as the discovery of novel circRNAs could be achieved. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 18% |
| Unspecified | 1 | 9% |
| Lecturer | 1 | 9% |
| Student > Ph. D. Student | 1 | 9% |
| Student > Master | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 4 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 4 | 36% |
| Unspecified | 1 | 9% |
| Computer Science | 1 | 9% |
| Unknown | 5 | 45% |