| Chapter title |
An Overview of Circular RNAs
|
|---|---|
| Chapter number | 1 |
| Book title |
Circular RNAs
|
| Published in |
Advances in experimental medicine and biology, September 2018
|
| DOI | 10.1007/978-981-13-1426-1_1 |
| Pubmed ID | |
| Book ISBNs |
978-9-81-131425-4, 978-9-81-131426-1
|
| Authors |
Rajendra Awasthi, Anurag Kumar Singh, Gaurav Mishra, Anand Maurya, Dinesh Kumar Chellappan, Gaurav Gupta, Philip Michael Hansbro, Kamal Dua |
| Abstract |
Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5'-3' polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker. CirRNAs can translate in vivo to link between their expression and disease. They are resistant to RNA exonuclease and can convert to the linear RNA by microRNA which can then act as competitor to endogenous RNA. This chapter summarizes the evolutionary conservation and expression of cirRNAs, their identification, highlighting various computational approaches on cirRNA, and translation with a focus on the breakthroughs and the challenges in this new field. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 20% |
| Student > Bachelor | 2 | 13% |
| Student > Doctoral Student | 1 | 7% |
| Lecturer > Senior Lecturer | 1 | 7% |
| Professor > Associate Professor | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 7 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 27% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Biochemistry, Genetics and Molecular Biology | 1 | 7% |
| Chemistry | 1 | 7% |
| Unknown | 8 | 53% |