| Chapter title |
Posttranslational lipid modification of rho family small GTPases.
|
|---|---|
| Chapter number | 6 |
| Book title |
Rho GTPases
|
| Published in |
Methods in molecular biology, January 2012
|
| DOI | 10.1007/978-1-61779-442-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-61779-441-4, 978-1-61779-442-1
|
| Authors |
Mitin N, Roberts PJ, Chenette EJ, Der CJ, Natalia Mitin, Patrick J. Roberts, Emily J. Chenette, Channing J. Der, Mitin, Natalia, Roberts, Patrick J., Chenette, Emily J., Der, Channing J. |
| Abstract |
The Rho family comprises a major branch of the Ras superfamily of small GTPases. A majority of Rho GTPases are synthesized as inactive, cytosolic proteins. They then undergo posttranslational modification by isoprenoid or fatty acid lipids, and together with additional carboxyl-terminal sequences target Rho GTPases to specific membrane and subcellular compartments essential for function. We summarize the use of biochemical and cellular assays and pharmacologic inhibitors instrumental for the study of the role of posttranslational lipid modifications and processing in Rho GTPase biology. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 21% |
| Researcher | 5 | 17% |
| Student > Master | 3 | 10% |
| Student > Bachelor | 2 | 7% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 10 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 41% |
| Agricultural and Biological Sciences | 4 | 14% |
| Business, Management and Accounting | 1 | 3% |
| Neuroscience | 1 | 3% |
| Unknown | 11 | 38% |