Chapter title |
Insulin-Like Growth Factor 1 in the Cardiovascular System
|
---|---|
Chapter number | 8 |
Book title |
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2018
|
DOI | 10.1007/112_2017_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-995287-1, 978-3-31-995288-8
|
Authors |
Gabriel A. Aguirre, José Luis González-Guerra, Luis Espinosa, Inma Castilla-Cortazar, Aguirre, Gabriel A., González-Guerra, José Luis, Espinosa, Luis, Castilla-Cortazar, Inma |
Abstract |
Non-communicable diseases, such as cardiovascular diseases, are the leading cause of mortality worldwide. For this reason, a tremendous effort is being made worldwide to effectively circumvent these afflictions, where insulin-like growth factor 1 (IGF1) is being proposed both as a marker and as a central cornerstone in these diseases, making it an interesting molecule to focus on. Firstly, at the initiation of metabolic deregulation by overfeeding, IGF1 is decreased/inhibited. Secondly, such deficiency seems to be intimately related to the onset of MetS and establishment of vascular derangements leading to atherosclerosis and finally playing a definitive part in cerebrovascular and myocardial accidents, where IGF1 deficiency seems to render these organs vulnerable to oxidative and apoptotic/necrotic damage. Several human cohort correlations together with basic/translational experimental data seem to confirm deep IGF1 implication, albeit with controversy, which might, in part, be given by experimental design leading to blurred result interpretation. |
Mendeley readers
Geographical breakdown
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 6 | 19% |
Student > Ph. D. Student | 4 | 13% |
Lecturer | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
Lecturer > Senior Lecturer | 2 | 6% |
Other | 6 | 19% |
Unknown | 10 | 31% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 2 | 6% |
Unknown | 11 | 34% |