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Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175

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Attention for Chapter 8: Insulin-Like Growth Factor 1 in the Cardiovascular System
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Chapter title
Insulin-Like Growth Factor 1 in the Cardiovascular System
Chapter number 8
Book title
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175
Published in
Reviews of Physiology, Biochemistry and Pharmacology, January 2018
DOI 10.1007/112_2017_8
Pubmed ID
Book ISBNs
978-3-31-995287-1, 978-3-31-995288-8
Authors

Gabriel A. Aguirre, José Luis González-Guerra, Luis Espinosa, Inma Castilla-Cortazar, Aguirre, Gabriel A., González-Guerra, José Luis, Espinosa, Luis, Castilla-Cortazar, Inma

Abstract

Non-communicable diseases, such as cardiovascular diseases, are the leading cause of mortality worldwide. For this reason, a tremendous effort is being made worldwide to effectively circumvent these afflictions, where insulin-like growth factor 1 (IGF1) is being proposed both as a marker and as a central cornerstone in these diseases, making it an interesting molecule to focus on. Firstly, at the initiation of metabolic deregulation by overfeeding, IGF1 is decreased/inhibited. Secondly, such deficiency seems to be intimately related to the onset of MetS and establishment of vascular derangements leading to atherosclerosis and finally playing a definitive part in cerebrovascular and myocardial accidents, where IGF1 deficiency seems to render these organs vulnerable to oxidative and apoptotic/necrotic damage. Several human cohort correlations together with basic/translational experimental data seem to confirm deep IGF1 implication, albeit with controversy, which might, in part, be given by experimental design leading to blurred result interpretation.

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Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 32 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 19%
Student > Ph. D. Student 4 13%
Lecturer 2 6%
Student > Doctoral Student 2 6%
Lecturer > Senior Lecturer 2 6%
Other 6 19%
Unknown 10 31%
Readers by discipline Count As %
Medicine and Dentistry 13 41%
Nursing and Health Professions 2 6%
Agricultural and Biological Sciences 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 6%
Unknown 11 34%