| Chapter title |
Potential of Cationic Liposomes as Adjuvants/Delivery Systems for Tuberculosis Subunit Vaccines
|
|---|---|
| Chapter number | 9 |
| Book title |
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175
|
| Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2018
|
| DOI | 10.1007/112_2018_9 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-995287-1, 978-3-31-995288-8
|
| Authors |
Farzad Khademi, Ramezan Ali Taheri, Amir Abbas Momtazi-Borojeni, Gholamreza Farnoosh, Thomas P. Johnston, Amirhossein Sahebkar |
| Abstract |
The weakness of the BCG vaccine and its highly variable protective efficacy in controlling tuberculosis (TB) in different age groups as well as in different geographic areas has led to intense efforts towards the development and design of novel vaccines. Currently, there are several strategies to develop novel TB vaccines. Each strategy has its advantages and disadvantages. However, the most important of these strategies is the development of subunit vaccines. In recent years, the use of cationic liposome-based vaccines has been considered due to their capacity to elicit strong humoral and cellular immune responses against TB infections. In this review, we aim to evaluate the potential for cationic liposomes to be used as adjuvants/delivery systems for eliciting immune responses against TB subunit vaccines. The present review shows that cationic liposomes have extensive applications either as adjuvants or delivery systems, to promote immune responses against Mycobacterium tuberculosis (Mtb) subunit vaccines. To overcome several limitations of these particles, they were used in combination with other immunostimulatory factors such as TDB, MPL, TDM, and Poly I:C. Cationic liposomes can provide long-term storage of subunit TB vaccines at the injection site, confer strong electrostatic interactions with APCs, potentiate both humoral and cellular (CD4 and CD8) immune responses, and induce a strong memory response by the immune system. Therefore, cationic liposomes can increase the potential of different TB subunit vaccines by serving as adjuvants/delivery systems. These properties suggest the use of cationic liposomes to produce an efficient vaccine against TB infections. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 9 | 15% |
| Student > Master | 7 | 12% |
| Student > Ph. D. Student | 6 | 10% |
| Researcher | 4 | 7% |
| Student > Doctoral Student | 2 | 3% |
| Other | 7 | 12% |
| Unknown | 24 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 10 | 17% |
| Immunology and Microbiology | 5 | 8% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Chemistry | 2 | 3% |
| Chemical Engineering | 2 | 3% |
| Other | 8 | 14% |
| Unknown | 29 | 49% |