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The LINC Complex

Overview of attention for book
Cover of 'The LINC Complex'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 EM Tomography of Meiotic LINC Complexes
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    Chapter 2 Recombinant Purification of the Periplasmic Portion of the LINC Complex
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    Chapter 3 Analysis of High Molecular Weight Isoforms of Nesprin-1 and Nesprin-2 with Vertical Agarose Gel Electrophoresis
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    Chapter 4 Analysis of Nesprin-2 Interaction with Its Binding Partners and Actin
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    Chapter 5 Interactions of Nesprin-4-Containing LINC Complexes in Outer Hair Cells Explored by BioID
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    Chapter 6 Using Nesprin Tension Sensors to Measure Force on the LINC Complex
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    Chapter 7 Analyzing Mechanotransduction Through the LINC Complex in Isolated Nuclei
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    Chapter 8 Direct Force Probe for Nuclear Mechanics
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    Chapter 9 Centrifugal Displacement of Nuclei in Adherent Cells to Study LINC Complex-Dependent Mechanisms of Homeostatic Nuclear Positioning
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    Chapter 10 Assembly and Use of a Microfluidic Device to Study Cell Migration in Confined Environments
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    Chapter 11 Investigating LINC Complex Protein Homo-oligomerization in the Nuclear Envelopes of Living Cells Using Fluorescence Fluctuation Spectroscopy
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    Chapter 12 Functional Analysis of the Yeast LINC Complex Using Fluctuation Spectroscopy and Super-Resolution Imaging
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    Chapter 13 Genetic Analysis of Nuclear Migration and Anchorage to Study LINC Complexes During Development of Caenorhabditis elegans
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    Chapter 14 High-Resolution Imaging Methods to Analyze LINC Complex Function During Drosophila Muscle Development
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    Chapter 15 Computational Methods for Studying the Plant Nucleus
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    Chapter 16 Investigation of Nuclear Periphery Protein Interactions in Plants Using the Membrane Yeast Two-Hybrid (MbY2H) System
  18. Altmetric Badge
    Chapter 17 Immunolabeling Protocols for Studying Meiosis in Plant Mutants Defective for Nuclear Envelope Components
  19. Altmetric Badge
    Chapter 18 Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice
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    Chapter 19 An In Vitro System to Measure the Positioning, Stiffness, and Rupture of the Nucleus in Skeletal Muscle
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    Chapter 20 Functional Analysis of LINC Complexes in the Skin
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    Chapter 21 Detection of SUN1 Splicing Variants at the mRNA and Protein Levels in Cancer
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    Chapter 22 Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins
Attention for Chapter 22: Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

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Chapter title
Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins
Chapter number 22
Book title
The LINC Complex
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8691-0_22
Pubmed ID
Book ISBNs
978-1-4939-8690-3, 978-1-4939-8691-0

Nagy, Peter L, Worman, Howard J, Peter L. Nagy, Howard J. Worman, Nagy, Peter L., Worman, Howard J.


Targeted panel, whole exome, or whole genome DNA sequencing using next-generation sequencing (NGS) allows for extensive high-throughput investigation of molecular machines/systems such as the LINC complex. This includes the identification of genetic variants in humans that cause disease, as is the case for some genes encoding LINC complex proteins. The relatively low cost and high speed of the sequencing process results in large datasets at various stages of analysis and interpretation. For those not intimately familiar with the process, interpretation of the data might prove challenging. This review lays out the most important and most commonly used materials and methods of NGS. It also discusses data analysis and potential pitfalls one might encounter because of peculiarities of the laboratory methodology or data analysis pipelines.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 20%
Other 2 13%
Student > Doctoral Student 2 13%
Student > Bachelor 1 7%
Student > Master 1 7%
Other 1 7%
Unknown 5 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 40%
Unspecified 1 7%
Agricultural and Biological Sciences 1 7%
Immunology and Microbiology 1 7%
Medicine and Dentistry 1 7%
Other 0 0%
Unknown 5 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 June 2019.
All research outputs
of 23,577,654 outputs
Outputs from Methods in molecular biology
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Outputs of similar age
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Outputs of similar age from Methods in molecular biology
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Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,410 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,160 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 1,482 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.