Chapter title |
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism.
|
---|---|
Chapter number | 404 |
Book title |
Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology
|
Published in |
Current topics in behavioral neurosciences, October 2015
|
DOI | 10.1007/7854_2015_404 |
Pubmed ID | |
Book ISBNs |
978-3-31-934134-7, 978-3-31-934136-1
|
Authors |
Ranger, Peter, Ellenbroek, Bart A, Peter Ranger, Bart A. Ellenbroek, Ellenbroek, Bart A. |
Abstract |
Valproic acid or valproate (VPA) is an anti-convulsant and mood stabiliser effective in treating epilepsy and bipolar disorders. Although in adults VPA is well tolerated and safe, there is convincing evidence that it has teratogenic properties, ranging from mild neurodevelopmental changes to severe congenital malformations. In particular, studies involving humans and other animals have shown that prenatal exposure to VPA can induce developmental abnormalities reminiscent of autism spectrum disorder (ASD). In this chapter, we discuss the connection between VPA and ASD, evaluate the VPA animal model of ASD, and describe the possible molecular mechanisms underlying VPA's teratogenic properties. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Hong Kong | 1 | 2% |
United States | 1 | 2% |
Argentina | 1 | 2% |
Unknown | 62 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 11% |
Student > Bachelor | 7 | 11% |
Student > Master | 7 | 11% |
Student > Doctoral Student | 5 | 8% |
Professor | 3 | 5% |
Other | 8 | 12% |
Unknown | 28 | 43% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 9 | 14% |
Psychology | 7 | 11% |
Medicine and Dentistry | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 5 | 8% |
Unknown | 30 | 46% |