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Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

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Cover of 'Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 394 Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D 2 Receptor
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    Chapter 395 Lifelong Rodent Model of Tardive Dyskinesia—Persistence After Antipsychotic Drug Withdrawal
  4. Altmetric Badge
    Chapter 396 Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson’s Disease
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    Chapter 397 Perinatal 6-Hydroxydopamine Modeling of ADHD
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    Chapter 398 Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment
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    Chapter 399 Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling.
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    Chapter 403 Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review.
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    Chapter 404 Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism.
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    Chapter 405 Neurobehavioral Effects from Developmental Methamphetamine Exposure
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    Chapter 409 Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings.
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    Chapter 411 Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection
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    Chapter 414 Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa
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    Chapter 415 Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl- d -Aspartate Receptors Systems
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    Chapter 416 Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases-an Overview of Experimental Studies.
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    Chapter 417 Perinatal Domoic Acid as a Neuroteratogen
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    Chapter 418 Perinatal 192 IgG-Saporin as Neuroteratogen.
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    Chapter 419 Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders
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    Chapter 420 NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems
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    Chapter 434 Neuroteratology and Animal Modeling of Brain Disorders
  21. Altmetric Badge
    Chapter 444 The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease
Attention for Chapter 404: Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism.
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Chapter title
Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism.
Chapter number 404
Book title
Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology
Published in
Current topics in behavioral neurosciences, October 2015
DOI 10.1007/7854_2015_404
Pubmed ID
Book ISBNs
978-3-31-934134-7, 978-3-31-934136-1
Authors

Ranger, Peter, Ellenbroek, Bart A, Peter Ranger, Bart A. Ellenbroek, Ellenbroek, Bart A.

Abstract

Valproic acid or valproate (VPA) is an anti-convulsant and mood stabiliser effective in treating epilepsy and bipolar disorders. Although in adults VPA is well tolerated and safe, there is convincing evidence that it has teratogenic properties, ranging from mild neurodevelopmental changes to severe congenital malformations. In particular, studies involving humans and other animals have shown that prenatal exposure to VPA can induce developmental abnormalities reminiscent of autism spectrum disorder (ASD). In this chapter, we discuss the connection between VPA and ASD, evaluate the VPA animal model of ASD, and describe the possible molecular mechanisms underlying VPA's teratogenic properties.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 2%
United States 1 2%
Argentina 1 2%
Unknown 63 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 14%
Researcher 7 11%
Student > Bachelor 7 11%
Student > Doctoral Student 5 8%
Professor 3 5%
Other 10 15%
Unknown 25 38%
Readers by discipline Count As %
Neuroscience 9 14%
Medicine and Dentistry 8 12%
Psychology 7 11%
Biochemistry, Genetics and Molecular Biology 5 8%
Pharmacology, Toxicology and Pharmaceutical Science 3 5%
Other 7 11%
Unknown 27 41%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2019.
All research outputs
#16,776,459
of 25,654,806 outputs
Outputs from Current topics in behavioral neurosciences
#320
of 516 outputs
Outputs of similar age
#166,514
of 296,096 outputs
Outputs of similar age from Current topics in behavioral neurosciences
#11
of 14 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 516 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,096 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.