| Chapter title |
Celiac Disease
|
|---|---|
| Chapter number | 6 |
| Book title |
Celiac Disease
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2839-2_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2838-5, 978-1-4939-2839-2
|
| Authors |
Kooy-Winkelaar, Yvonne, Koning, Frits, Yvonne Kooy-Winkelaar, Frits Koning |
| Abstract |
In patients with celiac disease, but not in healthy controls, gluten-specific CD4 T cells are present in the small intestinal lamina propria. Specific stimulation of these T cells due to gluten consumption leads to the release of pro-inflammatory cytokines, in particular IFNγ and IL-21. This leads to tissue damage, the typical morphological alterations like the flattening of the intestinal epithelium, and a variety of disease-associated symptoms including malnutrition, diarrhea, stomach ache, and failure to thrive. Removal of gluten from the diet eliminates the trigger for these CD4 T cells and leads to recovery. These CD4 T cells thus play a crucial role in the disease pathogenesis. Here we describe how such T cells can be isolated and characterized. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 10% |
| Unknown | 9 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 20% |
| Researcher | 2 | 20% |
| Student > Doctoral Student | 2 | 20% |
| Student > Master | 1 | 10% |
| Unknown | 3 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 2 | 20% |
| Immunology and Microbiology | 2 | 20% |
| Agricultural and Biological Sciences | 2 | 20% |
| Nursing and Health Professions | 1 | 10% |
| Unknown | 3 | 30% |