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Synthetic Gene Networks

Overview of attention for book
Cover of 'Synthetic Gene Networks'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 In silico implementation of synthetic gene networks.
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    Chapter 2 Standardization in synthetic biology.
  4. Altmetric Badge
    Chapter 3 Robust Optimal Design of Synthetic Biological Networks
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    Chapter 4 Predicting synthetic gene networks.
  6. Altmetric Badge
    Chapter 5 Reprogramming a GFP Reporter Gene Subjects It to Complex Lentiviral Gene Regulation
  7. Altmetric Badge
    Chapter 6 Synthetic Gene Networks
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    Chapter 7 Identifying and Optimizing Intracellular Protein–Protein Interactions Using Bacterial Genetic Selection
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    Chapter 8 Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines.
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    Chapter 9 RNA-Based Networks: Using RNA Aptamers and Ribozymes as Synthetic Genetic Devices
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    Chapter 10 MicroRNA Circuits for Transcriptional Logic.
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    Chapter 11 Light-regulated gene expression in yeast.
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    Chapter 12 Light-controlled gene switches in Mammalian cells.
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    Chapter 13 Expressed protein modifications: making synthetic proteins.
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    Chapter 14 Using Transcription Machinery Engineering to Elicit Complex Cellular Phenotypes
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    Chapter 15 Streamlining of a Pseudomonas putida Genome Using a Combinatorial Deletion Method Based on Minitransposon Insertion and the Flp-FRT Recombination System
  17. Altmetric Badge
    Chapter 16 Transposon-based and plasmid-based genetic tools for editing genomes of gram-negative bacteria.
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    Chapter 17 Synthetic Networks: Oscillators and Toggle Switches for Escherichia coli
  19. Altmetric Badge
    Chapter 18 Studying Microbial Communities in Biofilms
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    Chapter 19 Quantitative analysis of the spatiotemporal dynamics of a synthetic predator-prey ecosystem.
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    Chapter 20 Drosophila s2 schneider cells: a useful tool for rebuilding and redesigning approaches in synthetic biology.
  22. Altmetric Badge
    Chapter 21 Synthetic gene networks in plant systems.
  23. Altmetric Badge
    Chapter 22 Design and Construction of Synthetic Gene Networks in Mammalian Cells
  24. Altmetric Badge
    Chapter 23 Synthetic gene networks as blueprint for smart hydrogels.
Attention for Chapter 8: Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines.
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Chapter title
Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines.
Chapter number 8
Book title
Synthetic Gene Networks
Published in
Methods in molecular biology, January 2012
DOI 10.1007/978-1-61779-412-4_8
Pubmed ID
22083740
Book ISBNs
978-1-61779-411-7, 978-1-61779-412-4
Authors

Anne-Kathrin Dreyer, Toni Cathomen, Dreyer, Anne-Kathrin, Cathomen, Toni

Abstract

Customized zinc-finger nucleases (ZFNs) have developed into a promising technology to precisely alter mammalian genomes for biomedical research, biotechnology, or human gene therapy. In the context of synthetic biology, the targeted integration of a transgene or reporter cassette into a "neutral site" of the human genome, such as the AAVS1 locus, permits the generation of isogenic human cell lines with two major advantages over standard genetic manipulation techniques: minimal integration site-dependent effects on the transgene and, vice versa, no functional perturbation of the host-cell transcriptome. Here we describe in detail how ZFNs can be employed to target integration of a transgene cassette into the AAVS1 locus and how to characterize the targeted cells by PCR-based genotyping.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 6%
United States 1 6%
Unknown 15 88%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Researcher 4 24%
Professor 3 18%
Other 3 18%
Professor > Associate Professor 1 6%
Other 0 0%
Unknown 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 41%
Biochemistry, Genetics and Molecular Biology 3 18%
Medicine and Dentistry 2 12%
Neuroscience 1 6%
Unknown 4 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2011.
All research outputs
#18,300,116
of 22,656,971 outputs
Outputs from Methods in molecular biology
#7,803
of 13,015 outputs
Outputs of similar age
#195,908
of 244,031 outputs
Outputs of similar age from Methods in molecular biology
#325
of 473 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,015 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,031 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 473 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.

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