Chapter title |
Nilotinib
|
---|---|
Chapter number | 3 |
Book title |
Small Molecules in Hematology
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2018
|
DOI | 10.1007/978-3-319-91439-8_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-991438-1, 978-3-31-991439-8
|
Authors |
Martin Gresse, Theo D. Kim, Philipp le Coutre, Gresse, Martin, Kim, Theo D., le Coutre, Philipp |
Abstract |
With imatinib still being linked to the breakthrough in CML therapy and probably being the most prescribed drug, second-generation TKIs are increasingly gaining importance. Showing higher response rates while not leading to more adverse events, nilotinib has become an attractive option in the first-line treatment of chronic-phase chronic myeloid leukemia. By reaching deep and long-lasting molecular remissions, discontinuation of TKIs is becoming one of the central topics of future CML therapy. Stopping nilotinib seems safe and provides a stable remission in about half of the eligible patients, though long-term data are still missing. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Czechia | 1 | 1% |
Unknown | 86 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 12 | 14% |
Student > Ph. D. Student | 11 | 13% |
Other | 9 | 10% |
Student > Master | 8 | 9% |
Researcher | 7 | 8% |
Other | 12 | 14% |
Unknown | 28 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 29% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
Agricultural and Biological Sciences | 5 | 6% |
Nursing and Health Professions | 3 | 3% |
Other | 8 | 9% |
Unknown | 31 | 36% |