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Small Molecules in Hematology

Overview of attention for book
Cover of 'Small Molecules in Hematology'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Imatinib Mesylate
  3. Altmetric Badge
    Chapter 2 Dasatinib
  4. Altmetric Badge
    Chapter 3 Nilotinib
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    Chapter 4 Bosutinib: A Potent Second-Generation Tyrosine Kinase Inhibitor
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    Chapter 5 Ponatinib: A Third-Generation Inhibitor for the Treatment of CML
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    Chapter 6 Ruxolitinib
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    Chapter 7 Ibrutinib
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    Chapter 8 Pomalidomide
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    Chapter 9 Enasidenib
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    Chapter 10 Midostaurin: A Multiple Tyrosine Kinases Inhibitor in Acute Myeloid Leukemia and Systemic Mastocytosis
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    Chapter 11 Venetoclax: Targeting BCL2 in Hematological Cancers
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    Chapter 12 Idelalisib
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    Chapter 13 Carfilzomib
  15. Altmetric Badge
    Chapter 14 Acalabrutinib, A Second-Generation Bruton’s Tyrosine Kinase Inhibitor
Attention for Chapter 10: Midostaurin: A Multiple Tyrosine Kinases Inhibitor in Acute Myeloid Leukemia and Systemic Mastocytosis
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Chapter title
Midostaurin: A Multiple Tyrosine Kinases Inhibitor in Acute Myeloid Leukemia and Systemic Mastocytosis
Chapter number 10
Book title
Small Molecules in Hematology
Published in
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2018
DOI 10.1007/978-3-319-91439-8_10
Pubmed ID
30069632
Book ISBNs
978-3-31-991438-1, 978-3-31-991439-8
Authors

Richard F. Schlenk, Sabine Kayser, Schlenk, Richard F., Kayser, Sabine

Abstract

Midostaurin (PKC412, Rydapt®) is an oral multiple tyrosine kinase inhibitor. Main targets are the kinase domain receptor, vascular endothelial-, platelet derived-, and fibroblast growth factor receptor, stem cell factor receptor c-KIT, as well as mutated and wild-type FLT3 kinases. Midostaurin was approved by the Food and Drug Administration (FDA) and the European Medical Agency (EMA) for acute myeloid leukemia with activating FLT3 mutations in combination with intensive induction and consolidation therapy as well as aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated hematological neoplasm (SM-AHN) or mast cell leukemia (MCL). Several clinical trials are active or are planned to further investigate the role of midostaurin in myeloid malignancies and mastocytosis.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 19%
Student > Ph. D. Student 3 19%
Student > Master 2 13%
Student > Doctoral Student 1 6%
Researcher 1 6%
Other 2 13%
Unknown 4 25%
Readers by discipline Count As %
Medicine and Dentistry 4 25%
Biochemistry, Genetics and Molecular Biology 3 19%
Nursing and Health Professions 1 6%
Neuroscience 1 6%
Engineering 1 6%
Other 0 0%
Unknown 6 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 August 2018.
All research outputs
#20,529,173
of 23,098,660 outputs
Outputs from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#138
of 172 outputs
Outputs of similar age
#378,522
of 442,681 outputs
Outputs of similar age from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#18
of 22 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 172 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,681 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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