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Phosphodiesterases as Drug Targets

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Cover of 'Phosphodiesterases as Drug Targets'

Table of Contents

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    Book Overview
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    Chapter 1 Phosphodiesterase Inhibitors: History of Pharmacology
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    Chapter 2 Phosphodiesterase Inhibitors: Factors That Influence Potency, Selectivity, and Action
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    Chapter 3 Pharmacology, clinical efficacy, and tolerability of phosphodiesterase-4 inhibitors: impact of human pharmacokinetics.
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    Chapter 4 Structural Insight into the Substrate Specificity of Phosphodiesterases
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    Chapter 5 A Fission Yeast-Based Platform for Phosphodiesterase Inhibitor HTSs and Analyses of Phosphodiesterase Activity
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    Chapter 6 The GAF-Tandem Domain of Phosphodiesterase 5 as a Potential Drug Target
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    Chapter 7 Small Molecule Allosteric Modulators of Phosphodiesterase 4
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    Chapter 8 Regulation of Endothelial Barrier Function by Cyclic Nucleotides: The Role of Phosphodiesterases
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    Chapter 9 Phosphodiesterases as Targets for Intermittent Claudication
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    Chapter 10 Phosphodiesterase Inhibition in Heart Failure
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    Chapter 11 Phosphodiesterases: Emerging Therapeutic Targets for Neonatal Pulmonary Hypertension
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    Chapter 12 Role of Phosphodiesterases in Adult-Onset Pulmonary Arterial Hypertension
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    Chapter 13 Treatment of Erectile Dysfunction and Lower Urinary Tract Symptoms by Phosphodiesterase Inhibitors
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    Chapter 14 Evaluation of the Therapeutic Utility of Phosphodiesterase 5A Inhibition in the mdx Mouse Model of Duchenne Muscular Dystrophy
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    Chapter 15 Phosphodiesterases as Targets for Modulating T-Cell Responses
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    Chapter 16 Cyclic Nucleotides and Phosphodiesterases in Monocytic Differentiation
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    Chapter 17 Phosphodiesterase Inhibitors in the Treatment of Inflammatory Diseases
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    Chapter 18 Harnessing the Clinical Efficacy of Phosphodiesterase 4 Inhibitors in Inflammatory Lung Diseases: Dual-Selective Phosphodiesterase Inhibitors and Novel Combination Therapies
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    Chapter 19 Phosphodiesterases in the Central Nervous System: Implications in Mood and Cognitive Disorders
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    Chapter 20 Therapeutic Potential of Phosphodiesterase Inhibitors in Parasitic Diseases
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