| Chapter title |
Indole-3-Carbinol and Its Role in Chronic Diseases
|
|---|---|
| Chapter number | 6 |
| Book title |
Anti-inflammatory Nutraceuticals and Chronic Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-3-319-41334-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-941332-7, 978-3-31-941334-1
|
| Authors |
Barbara Licznerska, Wanda Baer-Dubowska, Licznerska, Barbara, Baer-Dubowska, Wanda |
| Abstract |
Indole-3-carbinol (I3C), a common phytochemical in cruciferous vegetables, and its condensation product, 3,3'-diindolylmethane (DIM) exert several biological activities on cellular and molecular levels, which contribute to their well-recognized chemoprevention potential. Initially, these compounds were classified as blocking agents that increase drug-metabolizing enzyme activity. Now it is widely accepted that I3C and DIM affect multiple signaling pathways and target molecules controlling cell division, apoptosis, or angiogenesis deregulated in cancer cells. Although most of the current data support the role of I3C and DIM in prevention of hormone-dependent cancers, it seems that their application in prevention of the other cancer as well as cardiovascular disease, obesity, and diabetes reduction is also possible. This chapter summarizes the current experimental data on the I3C and DIM activity and the results of clinical studies indicating their role in prevention of chronic diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 16% |
| Student > Master | 5 | 14% |
| Student > Ph. D. Student | 5 | 14% |
| Lecturer | 2 | 5% |
| Researcher | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 15 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Nursing and Health Professions | 2 | 5% |
| Chemistry | 2 | 5% |
| Medicine and Dentistry | 2 | 5% |
| Other | 1 | 3% |
| Unknown | 21 | 57% |