| Chapter title |
Garcinol and Its Role in Chronic Diseases
|
|---|---|
| Chapter number | 18 |
| Book title |
Anti-inflammatory Nutraceuticals and Chronic Diseases
|
| Published in |
Advances in experimental medicine and biology, January 2016
|
| DOI | 10.1007/978-3-319-41334-1_18 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-941332-7, 978-3-31-941334-1, 978-3-31-941332-7, 978-3-31-941334-1
|
| Authors |
Amit K. Behera, Mahadeva M. Swamy, Nagashayana Natesh, Tapas K. Kundu, Behera, Amit K., Swamy, Mahadeva M., Natesh, Nagashayana, Kundu, Tapas K. |
| Abstract |
The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature. Garcinol, a polyisoprenylated benzophenone, obtained from plant Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo. Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc., it is still in preclinical stage due to lack of systematic and conclusive evaluation of pharmacological parameters. While it is promising anti-cancer effects are being positively ascertained for therapeutic development, studies on its effectiveness in ameliorating other chronic diseases such as cardiovascular diseases, diabetes, allergy, neurodegenerative diseases etc., though seem favourable, are very recent and require in depth scientific investigation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 14% |
| Student > Postgraduate | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Master | 3 | 8% |
| Researcher | 3 | 8% |
| Other | 8 | 22% |
| Unknown | 10 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Chemistry | 3 | 8% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 14 | 38% |