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Anti-inflammatory Nutraceuticals and Chronic Diseases

Overview of attention for book
Cover of 'Anti-inflammatory Nutraceuticals and Chronic Diseases'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Curcumin and Its Role in Chronic Diseases
  3. Altmetric Badge
    Chapter 2 Anti-inflammatory Nutraceuticals and Chronic Diseases
  4. Altmetric Badge
    Chapter 3 Anti-inflammatory Nutraceuticals and Chronic Diseases
  5. Altmetric Badge
    Chapter 4 Ursolic Acid and Chronic Disease: An Overview of UA’s Effects On Prevention and Treatment of Obesity and Cancer
  6. Altmetric Badge
    Chapter 5 Tocotrienol and Its Role in Chronic Diseases
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    Chapter 6 Indole-3-Carbinol and Its Role in Chronic Diseases
  8. Altmetric Badge
    Chapter 7 Sanguinarine and Its Role in Chronic Diseases
  9. Altmetric Badge
    Chapter 8 Piperine and Its Role in Chronic Diseases
  10. Altmetric Badge
    Chapter 9 Anti-inflammatory Nutraceuticals and Chronic Diseases
  11. Altmetric Badge
    Chapter 10 Anti-inflammatory Nutraceuticals and Chronic Diseases
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    Chapter 11 Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
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    Chapter 12 Celastrol and Its Role in Controlling Chronic Diseases
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    Chapter 13 Boswellic Acids and Their Role in Chronic Inflammatory Diseases
  15. Altmetric Badge
    Chapter 14 Natural Withanolides in the Treatment of Chronic Diseases
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    Chapter 15 Gambogic Acid and Its Role in Chronic Diseases
  17. Altmetric Badge
    Chapter 16 Embelin and Its Role in Chronic Diseases
  18. Altmetric Badge
    Chapter 17 Butein and Its Role in Chronic Diseases
  19. Altmetric Badge
    Chapter 18 Garcinol and Its Role in Chronic Diseases
  20. Altmetric Badge
    Chapter 19 Morin and Its Role in Chronic Diseases
  21. Altmetric Badge
    Chapter 20 Ellagic Acid and Its Role in Chronic Diseases
Attention for Chapter 14: Natural Withanolides in the Treatment of Chronic Diseases
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#19 of 5,281)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
26 news outlets
blogs
1 blog
twitter
2 X users
wikipedia
1 Wikipedia page

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
187 Mendeley
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Chapter title
Natural Withanolides in the Treatment of Chronic Diseases
Chapter number 14
Book title
Anti-inflammatory Nutraceuticals and Chronic Diseases
Published in
Advances in experimental medicine and biology, January 2016
DOI 10.1007/978-3-319-41334-1_14
Pubmed ID
Book ISBNs
978-3-31-941332-7, 978-3-31-941334-1
Authors

Peter T. White, Chitra Subramanian, Hashim F. Motiwala, Mark S. Cohen

Abstract

Withanolides, and in particular extracts from Withania somnifera, have been used for over 3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within several other Asian countries. Traditionally, the extracts were ascribed a wide range of pharmacologic properties with corresponding medical uses, including adaptogenic, diuretic, anti-inflammatory, sedative/anxiolytic, cytotoxic, antitussive, and immunomodulatory. Since the discovery of the archetype withaferin A in 1965, approximately 900 of these naturally occurring, polyoxygenated steroidal lactones with 28-carbon ergostane skeletons have been discovered across 24 diverse structural types. Subsequently, extensive pharmacologic research has identified multiple mechanisms of action across key inflammatory pathways. In this chapter we identify and describe the major withanolides with anti-inflammatory properties, illustrate their role within essential and supportive inflammatory pathways (including NF-κB, JAK/STAT, AP-1, PPARγ, Hsp90 Nrf2, and HIF-1), and then discuss the clinical application of these withanolides in inflammation-mediated chronic diseases (including arthritis, autoimmune, cancer, neurodegenerative, and neurobehavioral). These naturally derived compounds exhibit remarkable biologic activity across these complex disease processes, while showing minimal adverse effects. As novel compounds and analogs continue to be discovered, characterized, and clinically evaluated, the interest in withanolides as a novel therapeutic only continues to grow.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 187 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 187 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 14%
Student > Bachelor 27 14%
Researcher 19 10%
Student > Master 13 7%
Student > Doctoral Student 11 6%
Other 28 15%
Unknown 62 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 24 13%
Medicine and Dentistry 19 10%
Agricultural and Biological Sciences 19 10%
Pharmacology, Toxicology and Pharmaceutical Science 13 7%
Chemistry 10 5%
Other 29 16%
Unknown 73 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 221. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 October 2023.
All research outputs
#173,033
of 25,307,660 outputs
Outputs from Advances in experimental medicine and biology
#19
of 5,281 outputs
Outputs of similar age
#2,794
of 406,439 outputs
Outputs of similar age from Advances in experimental medicine and biology
#2
of 448 outputs
Altmetric has tracked 25,307,660 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,281 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,439 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 448 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.