Chapter title |
Sirtuin1 (SIRT1) in the Acetylation of Downstream Target Proteins
|
---|---|
Chapter number | 12 |
Book title |
Histone Deacetylases
|
Published in |
Methods in molecular biology, January 2016
|
DOI | 10.1007/978-1-4939-3667-0_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3665-6, 978-1-4939-3667-0
|
Authors |
Ana R. Gomes, Jay Sze Yong, Khai Cheng Kiew, Ebru Aydin, Mattaka Khongkow, Sasiwan Laohasinnarong, Eric W.-F. Lam, Gomes, Ana R., Yong, Jay Sze, Kiew, Khai Cheng, Aydin, Ebru, Khongkow, Mattaka, Laohasinnarong, Sasiwan, Lam, Eric W.-F. |
Abstract |
Acetylation has been shown to be an important posttranslational modification (PTM) of both histone and nonhistone proteins with particular implications in cell signaling and transcriptional regulation of gene expression. Many studies have already demonstrated that SIRT1 is able to deacetylate histones and lead to gene silencing. It can also regulate the function of tumor suppressors including FOXO proteins and p53 by deacetylation. Here, we describe three experimental approaches for studying the modulation of the acetylation status of some of the known downstream targets of SIRT1. |
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