Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Michael Emerson, Emerson, Michael

Platelets are circulating blood elements with key roles in haemostasis and thrombosis. Platelets are activated by a range of stimuli including exposed subendothelial components. Haemostasis also depends upon the effects of inhibitory substances, including the gasotransmitter nitric oxide whose effects on platelets are well documented. Evidence is also emerging to suggest that H2S is generated enzymatically by platelets and can impact their function. Exposure of platelets to H2S from slow-release compounds inhibits aggregation and exerted anti-thrombotic effects in vivo. The mechanisms by which H2S impacts platelet function and the importance of interactions between H2S and other gasotransmitters remain unclear. H2S is therefore emerging as a potentially important regulator of platelet activation and thrombosis. Further study is required to evaluate its importance as a regulator of platelet physiology and associated pathological conditions such as myocardial infarction and stroke.