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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

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Cover of 'Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide'

Table of Contents

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    Book Overview
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    Chapter 1 H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects.
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    Chapter 2 Persulfidation (S-sulfhydration) and H 2 S
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    Chapter 3 Physiological Roles of Hydrogen Sulfide and Polysulfides
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    Chapter 4 H 2 S and Blood Vessels: An Overview
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    Chapter 5 Hydrogen Sulfide and Urogenital Tract
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    Chapter 6 H 2 S Is a Promoter of Angiogenesis: Identification of H 2 S “Receptors” and Its Molecular Switches in Vascular Endothelial Cells
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    Chapter 7 Hydrogen Sulfide and Platelets: A Possible Role in Thrombosis
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    Chapter 8 H 2 S and Inflammation: An Overview
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    Chapter 9 Hydrogen Sulfide and Neuroinflammation
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    Chapter 10 Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases.
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    Chapter 11 H 2 S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals
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    Chapter 12 Hydrogen Sulfide and Cancer.
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    Chapter 13 Role of H2S Donors in Cancer Biology.
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    Chapter 14 H2S: A New Approach to Lifespan Enhancement and Healthy Ageing?
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    Chapter 15 Fluorescent Probes for H 2 S Detection and Quantification
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    Chapter 16 The Pharmacological Effects of S -Propargyl-Cysteine, a Novel Endogenous H 2 S-Producing Compound
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    Chapter 17 Phosphinodithioate and Phosphoramidodithioate Hydrogen Sulfide Donors.
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    Chapter 18 Medicinal Chemistry: Insights into the Development of Novel H2S Donors
Attention for Chapter 18: Medicinal Chemistry: Insights into the Development of Novel H2S Donors
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Chapter title
Medicinal Chemistry: Insights into the Development of Novel H2S Donors
Chapter number 18
Book title
Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide
Published in
Handbook of experimental pharmacology, January 2015
DOI 10.1007/978-3-319-18144-8_18
Pubmed ID
26162844
Book ISBNs
978-3-31-918143-1, 978-3-31-918144-8
Authors

Yu Zhao, Armando Pacheco, Ming Xian, Zhao, Yu, Pacheco, Armando, Xian, Ming

Abstract

Hydrogen sulfide (H2S) was traditionally considered as a toxic gas. However, recent studies have demonstrated H2S is an endogenously generated gaseous signaling molecule (gasotransmitter) with importance on par with that of two other well-known endogenous gasotransmitters, nitric oxide (NO) and carbon monoxide (CO). Although H2S's exact mechanisms of action are still under investigation, the production of endogenous H2S and the exogenous administration of H2S have been demonstrated to elicit a wide range of physiological responses including modulation of blood pressure and protection of ischemia reperfusion injury, exertion of anti-inflammatory effects, and reduction of metabolic rate. These results strongly suggest that modulation of H2S levels could have potential therapeutic values. In this regard, synthetic H2S-releasing agents (i.e., H2S donors) are not only important research tools, but also potential therapeutic agents. This chapter summarizes the knowledge of currently available H2S donors. Their preparation, H2S releasing mechanisms, and biological applications are discussed.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 18%
Student > Ph. D. Student 4 18%
Researcher 3 14%
Student > Bachelor 2 9%
Student > Doctoral Student 1 5%
Other 2 9%
Unknown 6 27%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 4 18%
Biochemistry, Genetics and Molecular Biology 3 14%
Chemistry 3 14%
Medicine and Dentistry 2 9%
Agricultural and Biological Sciences 2 9%
Other 0 0%
Unknown 8 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2017.
All research outputs
#20,459,801
of 23,016,919 outputs
Outputs from Handbook of experimental pharmacology
#573
of 647 outputs
Outputs of similar age
#297,033
of 354,221 outputs
Outputs of similar age from Handbook of experimental pharmacology
#58
of 65 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 647 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,221 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

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