| Chapter title |
Glutamate Fermentation-2: Mechanism of l -Glutamate Overproduction in Corynebacterium glutamicum
|
|---|---|
| Chapter number | 26 |
| Book title |
Amino Acid Fermentation
|
| Published in |
Advances in biochemical engineering biotechnology, January 2016
|
| DOI | 10.1007/10_2016_26 |
| Pubmed ID | |
| Book ISBNs |
978-4-43-156518-5, 978-4-43-156520-8
|
| Authors |
Takashi Hirasawa, Masaaki Wachi, Hirasawa, Takashi, Wachi, Masaaki |
| Abstract |
The nonpathogenic coryneform bacterium, Corynebacterium glutamicum, was isolated as an L-glutamate-overproducing microorganism by Japanese researchers and is currently utilized in various amino acid fermentation processes. L-Glutamate production by C. glutamicum is induced by limitation of biotin and addition of fatty acid ester surfactants and β-lactam antibiotics. These treatments affect the cell surface structures of C. glutamicum. After the discovery of C. glutamicum, many researchers have investigated the underlying mechanism of L-glutamate overproduction with respect to the cell surface structures of this organism. Furthermore, metabolic regulation during L-glutamate overproduction by C. glutamicum, particularly, the relationship between central carbon metabolism and L-glutamate biosynthesis, has been investigated. Recently, the role of a mechanosensitive channel protein in L-glutamate overproduction has been reported. In this chapter, mechanisms of L-glutamate overproduction by C. glutamicum have been reviewed. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 2% |
| Unknown | 50 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 22% |
| Student > Ph. D. Student | 6 | 12% |
| Researcher | 6 | 12% |
| Student > Master | 4 | 8% |
| Student > Doctoral Student | 3 | 6% |
| Other | 2 | 4% |
| Unknown | 19 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 29% |
| Agricultural and Biological Sciences | 8 | 16% |
| Engineering | 2 | 4% |
| Environmental Science | 1 | 2% |
| Chemical Engineering | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 21 | 41% |