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Enzyme Kinetics in Drug Metabolism

Overview of attention for book
Cover of 'Enzyme Kinetics in Drug Metabolism'

Table of Contents

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    Book Overview
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    Chapter 1 Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications
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    Chapter 2 Fundamentals of Enzyme Kinetics
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    Chapter 3 Different Enzyme Kinetic Models
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    Chapter 4 Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance
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    Chapter 5 Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions
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    Chapter 6 Multienzyme Kinetics and Sequential Metabolism
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    Chapter 7 Consideration of the Unbound Drug Concentration in Enzyme Kinetics
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    Chapter 8 Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450
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    Chapter 9 Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
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    Chapter 10 Enzyme Kinetics of Conjugating Enzymes: PAPS Sulfotransferase
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    Chapter 11 Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
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    Chapter 12 Principles and Experimental Considerations for In Vitro Transporter Interaction Assays
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    Chapter 13 Rationalizing Underprediction of Drug Clearance from Enzyme and Transporter Kinetic Data: From In Vitro Tools to Mechanistic Modeling
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    Chapter 14 A Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
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    Chapter 15 Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
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    Chapter 16 Variability in Human In Vitro Enzyme Kinetics
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    Chapter 17 Sources of interindividual variability.
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    Chapter 18 Case Study 1. Practical Considerations with Experimental Design and Interpretation
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    Chapter 19 Case Study 2. Practical Analytical Considerations for Conducting In Vitro Enzyme Kinetic Studies
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    Chapter 20 Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies: Real-Life Examples
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    Chapter 21 Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
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    Chapter 22 Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2, or OATP1B1 in Drug Development
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    Chapter 23 Case Study 6. Transporter Case Studies: In Vitro Solutions for Translatable Outcomes
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    Chapter 24 Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors’ Experiences
Attention for Chapter 8: Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450
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  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Mentioned by

wikipedia
2 Wikipedia pages

Readers on

mendeley
22 Mendeley
citeulike
1 CiteULike
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Chapter title
Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450
Chapter number 8
Book title
Enzyme Kinetics in Drug Metabolism
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-62703-758-7_8
Pubmed ID
Book ISBNs
978-1-62703-757-0, 978-1-62703-758-7
Authors

Ken Korzekwa, Korzekwa, Ken

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 18%
Researcher 4 18%
Student > Postgraduate 3 14%
Student > Ph. D. Student 3 14%
Student > Bachelor 3 14%
Other 3 14%
Unknown 2 9%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 8 36%
Biochemistry, Genetics and Molecular Biology 4 18%
Agricultural and Biological Sciences 4 18%
Chemical Engineering 1 5%
Decision Sciences 1 5%
Other 3 14%
Unknown 1 5%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2023.
All research outputs
#8,315,603
of 24,874,764 outputs
Outputs from Methods in molecular biology
#2,570
of 13,968 outputs
Outputs of similar age
#96,661
of 317,839 outputs
Outputs of similar age from Methods in molecular biology
#104
of 564 outputs
Altmetric has tracked 24,874,764 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,968 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,839 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 564 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.