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Enzyme Kinetics in Drug Metabolism

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Cover of 'Enzyme Kinetics in Drug Metabolism'

Table of Contents

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    Book Overview
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    Chapter 1 Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications
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    Chapter 2 Fundamentals of Enzyme Kinetics
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    Chapter 3 Different Enzyme Kinetic Models
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    Chapter 4 Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance
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    Chapter 5 Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions
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    Chapter 6 Multienzyme Kinetics and Sequential Metabolism
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    Chapter 7 Consideration of the Unbound Drug Concentration in Enzyme Kinetics
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    Chapter 8 Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450
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    Chapter 9 Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
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    Chapter 10 Enzyme Kinetics of Conjugating Enzymes: PAPS Sulfotransferase
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    Chapter 11 Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
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    Chapter 12 Principles and Experimental Considerations for In Vitro Transporter Interaction Assays
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    Chapter 13 Rationalizing Underprediction of Drug Clearance from Enzyme and Transporter Kinetic Data: From In Vitro Tools to Mechanistic Modeling
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    Chapter 14 A Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
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    Chapter 15 Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
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    Chapter 16 Variability in Human In Vitro Enzyme Kinetics
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    Chapter 17 Sources of interindividual variability.
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    Chapter 18 Case Study 1. Practical Considerations with Experimental Design and Interpretation
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    Chapter 19 Case Study 2. Practical Analytical Considerations for Conducting In Vitro Enzyme Kinetic Studies
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    Chapter 20 Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies: Real-Life Examples
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    Chapter 21 Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
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    Chapter 22 Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2, or OATP1B1 in Drug Development
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    Chapter 23 Case Study 6. Transporter Case Studies: In Vitro Solutions for Translatable Outcomes
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    Chapter 24 Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors’ Experiences
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Title
Enzyme Kinetics in Drug Metabolism
Published by
Humana Press, February 2014
DOI 10.1007/978-1-62703-758-7
ISBNs
978-1-62703-757-0, 978-1-62703-758-7
Editors

Nagar, Swati, Argikar, Upendra A., Tweedie, Donald J.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 107 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 <1%
Unknown 106 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 29%
Student > Master 18 17%
Researcher 17 16%
Student > Bachelor 14 13%
Professor > Associate Professor 4 4%
Other 16 15%
Unknown 7 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 25%
Chemistry 17 16%
Pharmacology, Toxicology and Pharmaceutical Science 11 10%
Biochemistry, Genetics and Molecular Biology 11 10%
Engineering 10 9%
Other 20 19%
Unknown 11 10%