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Enzyme Kinetics in Drug Metabolism

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Cover of 'Enzyme Kinetics in Drug Metabolism'

Table of Contents

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    Book Overview
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    Chapter 1 Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications
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    Chapter 2 Fundamentals of Enzyme Kinetics
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    Chapter 3 Different Enzyme Kinetic Models
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    Chapter 4 Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance
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    Chapter 5 Irreversible Enzyme Inhibition Kinetics and Drug–Drug Interactions
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    Chapter 6 Multienzyme Kinetics and Sequential Metabolism
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    Chapter 7 Consideration of the Unbound Drug Concentration in Enzyme Kinetics
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    Chapter 8 Enzyme Kinetics of Oxidative Metabolism: Cytochromes P450
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    Chapter 9 Enzyme Kinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase
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    Chapter 10 Enzyme Kinetics of Conjugating Enzymes: PAPS Sulfotransferase
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    Chapter 11 Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs)
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    Chapter 12 Principles and Experimental Considerations for In Vitro Transporter Interaction Assays
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    Chapter 13 Rationalizing Underprediction of Drug Clearance from Enzyme and Transporter Kinetic Data: From In Vitro Tools to Mechanistic Modeling
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    Chapter 14 A Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
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    Chapter 15 Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism
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    Chapter 16 Variability in Human In Vitro Enzyme Kinetics
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    Chapter 17 Sources of interindividual variability.
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    Chapter 18 Case Study 1. Practical Considerations with Experimental Design and Interpretation
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    Chapter 19 Case Study 2. Practical Analytical Considerations for Conducting In Vitro Enzyme Kinetic Studies
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    Chapter 20 Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies: Real-Life Examples
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    Chapter 21 Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast
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    Chapter 22 Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A1, MRP2, or OATP1B1 in Drug Development
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    Chapter 23 Case Study 6. Transporter Case Studies: In Vitro Solutions for Translatable Outcomes
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    Chapter 24 Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors’ Experiences
Attention for Chapter 14: A Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
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Chapter title
A Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers
Chapter number 14
Book title
Enzyme Kinetics in Drug Metabolism
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-62703-758-7_14
Pubmed ID
24523118
Book ISBNs
978-1-62703-757-0, 978-1-62703-758-7
Authors

Joe Bentz, Harma Ellens, Bentz, Joe, Ellens, Harma

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 50%
Student > Bachelor 1 25%
Unknown 1 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 50%
Decision Sciences 1 25%
Unknown 1 25%

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