Chapter title |
Treatment Options for Central Sleep Apnea: Comparison of Ventilator, Oxygen, and Drug Therapies
|
---|---|
Chapter number | 183 |
Book title |
Respiratory Contagion
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/5584_2015_183 |
Pubmed ID | |
Book ISBNs |
978-3-31-930603-2, 978-3-31-930604-9
|
Authors |
Josef Yayan, Kurt Rasche |
Abstract |
Central sleep apnea (CSA) is a sleep-related disorder characterized by pauses in breathing during sleep when the brain respiratory network momentarily interrupts transmission of impulses to the respiratory musculature. CSA presents significant problems being an independent risk factor for cardiovascular events and death. There are several available treatment options according to CSA severity. Currently, adaptive servo-ventilation is considered best for CSA patients. The goal of the present study was to retrospectively investigate different treatment methods employed for CSA, such as different modes of ventilation, oxygen therapy, and drugs to determine the most effective one. Data were obtained from hospital records during 2010-2015. The diagnosis of CSA and the optimal treatment method were supported by polysomnography examinations. Devices used during sleep to support breathing included continuous positive airway pressure, bi-level positive airway pressure, or adaptive servo-ventilation. We classified 71 (2.9 %) patients as having CSA from 2,463 patients with sleep-disordered breathing. Of those 71 patients, 54 (76.1 %, 95 % CI 66.2-86.0 %) were male and 17 (23.9 %, 95 % CI 14.0-33.8 %) were female, and they had a mean age of 67.1 ± 14.1. Four (5.6 %) patients underwent a combination therapy, 39 (54.9 %) received a ventilator in proper ventilation mode, 25 (35.2 %) received oxygen therapy, 7 (9.9 %) received medication, and 4 (5.6 %) received no treatment. We conclude that although the majority of patients needed treatment for central sleep apnea, a clear advantage in using ventilators when compared to oxygen therapy or drug therapy could not be found. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 36 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 22% |
Other | 5 | 14% |
Student > Bachelor | 5 | 14% |
Researcher | 5 | 14% |
Student > Doctoral Student | 2 | 6% |
Other | 4 | 11% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 18 | 50% |
Nursing and Health Professions | 2 | 6% |
Unspecified | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 5 | 14% |
Unknown | 8 | 22% |