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Vitamin D Analogs in Cancer Prevention and Therapy

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Cover of 'Vitamin D Analogs in Cancer Prevention and Therapy'

Table of Contents

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    Book Overview
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    Chapter 1 Evolution and function of vitamin D.
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    Chapter 2 Current Understanding of the Function of the Nuclear Vitamin D Receptor in Response to Its Natural and Synthetic Ligands
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    Chapter 3 Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk
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    Chapter 4 Ligand Structure—Function Relationships in the Vitamin D Endocrine System from the Perspective of Drug Development (Including Cancer Treatment)
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    Chapter 5 Antiproliferative signalling by 1,25(OH)2D3 in prostate and breast cancer is suppressed by a mechanism involving histone deacetylation.
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    Chapter 6 Mechanisms Implicated in the Growth Regulatory Effects of Vitamin D Compounds in Breast Cancer Cells
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    Chapter 7 Squamous Cell Carcinomas Fail to Respond to the Prodifferentiating Actions of 1,25(OH) 2 D 3 : Why?
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    Chapter 8 A Novel Vitamin D-Regulated Immediate-Early Gene, IEX-1, Alters Cellular Growth and Apoptosis
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    Chapter 9 Extrarenal Sites of Calcitriol Synthesis:The Particular Role of the Skin
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    Chapter 10 Cultured Rat Growth Plate Chondrocytes Express Low Levels of 1α-Hydroxylase
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    Chapter 11 Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression?
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    Chapter 12 Regulation of the 25-Hydroxyvitamin D-1α-Hydroxylase Gene and Its Splice Variant
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    Chapter 13 Combination of Vitamin D Metabolites with Selective Inhibitors of Vitamin D Metabolism
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    Chapter 14 Importance Of Cytochrome P450-Mediated Metabolism in the Mechanism of Action of Vitamin D Analogs
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    Chapter 15 The Role of Vitamin D in Prostate Cancer
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    Chapter 16 Vitamin D Autocrine System and Prostate Cancer
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    Chapter 17 Analysis of the Vitamin D System in Cervical Carcinomas, Breast Cancer and Ovarian Cancer
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    Chapter 18 Short-Chain Fatty Acids and Colon Cancer Cells: The Vitamin D Receptor—Butyrate Connection
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    Chapter 19 Analysis of the Vitamin D system in Cutaneous Malignancies
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    Chapter 20 Evaluation of vitamin D analogs as therapeutic agents for prostate cancer.
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    Chapter 21 Design, Synthesis, and Biological Studies of the A-Ring-Modified 1,25-Dihydroxyvitamin D 3 Analogs
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    Chapter 22 Induction of Apoptosis by Vitamin D Metabolites and Analogs in a Glioma Cell Line
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    Chapter 23 Vitamin D Analogs and Breast Cancer
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    Chapter 24 A Low-Calcemic Vitamin D Analog (Ro 25-4020) Inhibits the Growth of LNCaP Human Prostate Cancer Cells with Increased Potency by Producing an Active 24-Oxo Metabolite (Ro 29-9970)
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    Chapter 25 Prospects for Vitamin D receptor Modulators as Candidate Drugs for Cancer and (Auto)immune Diseases
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    Chapter 26 The Role of Reactive Oxygen Species in the Anticancer Activity of Vitamin D
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    Chapter 27 Ecologic Studies of Solar UV-B Radiation and Cancer Mortality Rates
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    Chapter 28 Phytoestrogens and 17β-Estradiol Influence Vitamin D Metabolism and Receptor Expression—Relevance for Colon Cancer Prevention
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    Chapter 29 Efficacy and Mechanism of Action of 1α-hydroxy-24-ethyl-Cholecalciferol (1α[OH]D5) in Breast Cancer Prevention and Therapy
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    Chapter 30 Regulation of Extrarenal Vitamin D Metabolism as a Tool for Colon and Prostate Cancer Prevention
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    Chapter 31 Modulation of X-ray-Induced Apoptosis in Human Keratinocytes (HaCaT) by 1,25-Dihydroxyvitamin D 3
Attention for Chapter 11: Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression?
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Chapter title
Gene amplification and splice variants of 25-hydroxyvitamin D3 1,alpha-hydroxylase (CYP27B1) in glioblastoma multiforme--a possible role in tumor progression?
Chapter number 11
Book title
Vitamin D Analogs in Cancer Prevention and Therapy
Published in
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2003
DOI 10.1007/978-3-642-55580-0_11
Pubmed ID
12899520
Book ISBNs
978-3-64-262435-3, 978-3-64-255580-0
Authors

Diesel, Britta, Fischer, Ulrike, Meese, Eckart, Britta Diesel, Ulrike Fischer, Eckart Meese

Abstract

We report a gene amplification of 25-hydroxyvitamin D3 1,alpha-hydroxylase and the appearance of various splice variants in glioblastoma multiforme. Some protein products of the widespread expressed variants may exert a biological function. The analysis of amplification and overexpression of alternative transcripts will provide new insights in the regulation of the 25-hydroxyvitamin D3 1,alpha-hydroxylase expression and may have implications for prognosis in glioblastoma.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 13%
Unknown 7 88%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Student > Doctoral Student 1 13%
Other 1 13%
Student > Ph. D. Student 1 13%
Student > Bachelor 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 38%
Biochemistry, Genetics and Molecular Biology 2 25%
Medicine and Dentistry 1 13%
Unknown 2 25%

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